胡学强 陆正齐 饶从志 510630 广州, 中山医科大学附属第三医院神经内科 中华神经科杂志 1998 0 31 4


    关键词：脑脊髓炎；变应性；；脑脊髓液；；细胞学；成束猴 期刊 zhsjkzz 0 *论著* fur -->


    

【摘要】 目的 研究猴实验性变态反应性脑脊髓炎(EAE)的脑脊液细胞学与临床病情及病程的相关性。方法 将11只食蟹猴分为对照组(1只)和EAE组(10只)。用新鲜食蟹猴脑的白质，制成脑白质匀浆乳化液，在猴多部位皮下注射，制成EAE模型。每周抽取0.5ml脑脊液，用微量细胞玻片离心沉淀法收集脑脊液细胞, 迈-格-姬染色法染色,用带有测微仪的显微镜进行细胞计数和分类。结果 猴EAE的脑脊液细胞数与病情呈明显正相关(P≤0.01)。结论 动态监测猴EAE脑脊液细胞学可反映病情变化；脑脊液细胞数变化可以预告病情复发或进展。

    A study on correlation among cerebrospinal fluid cytology inmonkeys with experimental allergic encephalomyelitis, clinical illness and courses Hu Xueqiang, Lu Zhengqi, Rao Congzhi. Department ofNeurology, Third Affiliated Hospital, Sun Yatsen University of Medical Sciences, Guangzhou510630

    【Abstract】 Objective To investigate therelationship among cerebrospinal fluid (CSF) cytology clinical conditions and courses ofEAE in cynomolgus monkeys with experimental allergic encephalomyelitis (EAE). Method CSF cells were collected by slide centri-fugation and stainedby May-Grunwald-Giemsa(MGG) assay, the cell counts and differentiation were performed bymicroscope with micrometer. Results CSF cell countswere positively related to clinical conditions. In addition, CSF cell counts modificationmay foretell. Conclusion These findings indicatedmonitoring serially CSF cytology may predict the clinical recurrence or progression of EAE.

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