【摘要】 目的 研究长期服用雷公藤对系统性红斑狼疮患者骨骼系统的远期影响。方法 采用灵敏度高的双能X线骨矿物质密度测定仪对71例系统性红斑狼疮患者及其按年龄、性别、体重、身高相配对的健康对照者进行腰椎骨矿物质密度测定。结果 长期服用雷公藤组患者腰椎骨密度显著下降，其骨密度下降程度与累计服药时间有关。结论 长期服用雷公藤对系统性红斑狼疮患者骨骼系统有显著影响，使之以后发生骨质疏松和骨折的危险度增加，应引起临床医师的重视。

    The Effect on Bone Mineral Density in SLE Patients After Long-term Administration ofTripterygium Wilfordii Hook F. Huang Lan,Feng Shufang,Wang Hongfu.Departmentof Dermatology,Huashan Hospital,Shanghai Medical University,Shanghai 200040

    【Abstract 】 Objective To investigate the effect on skeletal system in SLE patients after long-term administration of Tripterygium Wilfordii(TW). Methods The bone mineral density(BMD) of lumbar vertebrae 2 ～4 was detected by dual energy X-ray absorptiometry (DXA) with high sensitivity in 71 SLE patients and healthy controls matched with age,sex,

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