刘树芬 张波 张劭夫 张霞 丁元吉 250031 济南，济南军区总院呼吸科(刘树芬、张波、张劭夫)，病理科(张霞、丁元吉) 中华结核和呼吸感染 1998 12 21 12


    关键词：肺肿瘤；生长因子；转移；免疫组织化学 期刊 zhjhhhxgr 0 论 著 fur -->


    

【摘要 】 目的 探讨肺癌细胞生长因子受体的表达及其与淋巴结转移的关系。方法 采用免疫组织化学法对肺癌组织切片中抗表皮生长因子受体(EGFR)，血小板源性生长因子受体(PDGFR)和胰岛素样生长因子-1受体(IGF-1R)的表达进行检测。结果 肺鳞癌EGFR、PDGFR和IGF-1R的阳性率分别为80%、85%和75%；腺癌为88%、88%和81%；小细胞癌为80%、70%和80%；而正常肺组织仅分别为20%、10%和20%(P<0.05)；Ⅲ期肺癌EGFR、PDGFR和IGF-1R的阳性率分别为88%、80%、90%；Ⅱ期肺癌分别为52%、43%、57%(P<0.05)；肺癌细胞三种生长因子受体表达均较正常组织为高。Ⅲ期患者生长因子受体表达明显高于Ⅱ期患者。结论 EGFR、PDGFR及IGF-1R的表达与肺癌生长分化、转移等恶性行为密切相关。

Expression ofepidermal growth factor receptor (EGFR), platelet growth factor receptor (PGFR) andinsulin growth factor-1 receptor (IGF-1R) on lung cancer cell

Liu Shufen, Zhang Bo, Zhang Shaofu, et al. Department of Respiration, Jinan General Military Hospital, Jinan 250031

【 Abstract 】 Objective To evaluate the expression ofgrowth factor receptors (GFRs) on lung cancer cells and the relation between theexpression of GFRs and metastasis of lung cancer. Method The expression of EGFR, PDGFR andIGF-1R was detected with immunohistochemical method using monoclonal antibodies. Result The expression of EGFR, PDGFR andIGF-1R showed higher positive rates in lung cancer cells than those in normal lungtissues, and the expression was increased as the disease was advanced. Conclusion The increased expression of EGFR,PDGFR and IGF-1R is related with the metastasis of lung cancer.

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