程淑 杨池荪 李诗兰 100083 北京医科大学第三临床医学院妇产科 中华围产医学杂志 1999 0 0 1


    关键词：妊娠并发症；心血管；高血压；胎盘；内皮生长因子 期刊 zhwcyxzz 0 论 著 fur -->


    

【摘要】 目的 观察血管内皮生长因子(VEGF)在妊高征(PIH)胎盘中的变化。 方法 用免疫组织化学法，检测20例正常妊娠胎盘(对照组)和23例妊高征胎盘(妊高征组)中VEGF的水平。 结果 VEGF在正常妊娠胎盘和妊高征胎盘中分布基本一致，分布在滋养细胞、血管及绒毛间质。在妊高征组VEGF为轻度表达占79.2%，无重度表达；而在对照组VEGF轻度表达占25%，中度表达占45%，重度表达占30%。妊高征组中VEGF表达明显低于对照组(P<0.01)。 结论 妊高征胎盘中VEGF的减少可能与胎盘血管生成减少及胎盘滋养叶细胞侵入异常有关，在妊高征发病中占有一定的地位。

    Expression of VascularEndothelial Growth Factor in Placenta in Normal Pregnancy and Patients with PregnancyInduced Hypertension

ChengShu,Yang Chisun,Li Shilan.Department of Obstetrics & Gynecology,The Third Hospital ofBeijing Medical University,Beijing, 100083

【 Abstract】 Objective To investigate the change of vascular endothelial growthfactor (VEGF) in placenta from patients with pregnancy induced hypertension(PIH). Methods The expression of VEGF in 20placentas from normal pregnancy (normal group)and 23 placentas from PIH(PIH group)isdetected by imnunohistochemistry. Results The distribution of VEGF in placenta of normal group issimilar to that of PIH group.They all are found in villous trophoblast,villous bloodvessels and villous strome.VEGF is light expressed mostly in placenta of PIH group,about79.2% and there is no strong expression.In normal placenta light expression is only25%,the moderate is 45% and strong is 30%.The level of VEGF was significantly lower in PIHgroup than that in normal group(P<0.01). Conclusion The decrease of VEGF in placenta from PIH may be relatedto inadequete blood vessel formation and the abnormal invasions of trophoblast and mayplay a role in the cause of PIH.

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