于秀淳 刘晓平 曲在屏 周银 丁吉 250031 济南，解放军济南军区总医院骨病科 中华放射学杂志 1999 0 33 9


    关键词：骨肿瘤；基因表达；放射摄影术；对比研究 期刊 zhfsxzz 0 骨骼肌肉系统放射学 fur -->


    

【摘要】 目的 探讨骨肿瘤X线征象与肿瘤细胞增殖细胞核抗原(PCNA)表达间的相互关系。方法 分析34例骨肿瘤X线表现，根据病变的性质、边界、骨皮质的完整性、病变大小,以及有无骨膜反应、软组织肿块和是否存在病理骨折等分类；应用免疫组化的方法测定肿瘤细胞PCNA阳性率的表达。结果 经统计学分析，PCNA阳性率与病变的性质、大小、骨皮质的完整性以及是否存在病理骨折密切相关；与软组织肿块、有无骨膜反应及病变边界无关。结论 从细胞分子水平证明，分析骨肿瘤的X线征象，有助于了解肿瘤细胞的增殖能力，指导临床采取正确的治疗方法。

    

The relationship betweenbone tumor X-ray manifestation and tumor cell proliferated cell neuclear antigenexpression

YU Xiuchun, LIU Xiaoping, QU Zaiping, et al.

    (Jinan Military General Hospital， Jinan 250031)

【 Abstract 】 Objective To investigate the relationship between bone tumor X-raycharacteristics and tumor cell proliferation cell nuclear antigen (PCNA) expression. Methods Analysing the X-raymanifestations of 34 bone tumor. Classfying them according to the nature of disease, edge,cortical bone integrity, periosteal reaction, tumor size, soft-tissue mass, andpathological fracture. Tumor cell PCNA expression was determined with immunohistochemicalmethod. Results The PCNA positive expression rate was related to the tumornature, size, bone integrity and pathological fracture, but not related with the softtissue mass, periosteal reaction and the tumor edge. Conclusions The results indicate that it ishelpful to analyse the X-ray manifestions of bone tumor carefully for better understandingof tumor cell proliferation ability.

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