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外照射慢性放射病的胸腺肽治疗及追踪观察
http://www.100md.com 《中华放射医学与防护杂志》 1998年第4期
外照射慢性放射病|胸腺肽|追踪观察|综合判断标准,关键词:
外照射慢性放射病的胸腺肽治疗及追踪观察
外照射慢性放射病的胸腺肽治疗及追踪观察

     高慎永 孙文佶 张爱珍 叶安方 310003 杭州,浙江医科大学附属第一医院放射医学研究室 中华放射医学与防护杂志 1998 0 18 4


    关键词:外照射慢性放射病;胸腺肽;追踪观察;综合判断标准 期刊 zhfsyxyfhzz 0 人的放射病 fur -->


    

目的 本文观察11例慢性放射病的胸腺肽治疗结果及病程转归。方法 以临床征状变化、造血系统造血功能、T淋巴细胞百分率、染色体畸变率变化作为慢放病恢复的综合判断标准进行分析。结果 胸腺肽能促使患者的无力型神经衰弱征候群明显好转;能显著提高T淋巴细胞百分率,进而增强机体免疫力,治愈口腔粘膜溃疡。追踪观察表明,慢放病恢复时间依次为细胞免疫功能(2年),无力型神经衰弱综合症(3.5年),造血组织造血功能(5~8年),染色体畸变率(10年)。结论 按照我们拟定的慢放病恢复综合判断标准,慢放病是一种可以恢复的职业性疾病。胸腺肽有助于慢放病的治疗,具方法简单,值得临床试用。

Long-term follow-upobservation of patients with chronic radiation sickness due to external irradiationtreated with thymopeptide. Gao Shenyong,Sun Wenji,Zhang Aizhen,et al.Dept.ofRadiation Medicine,The First Affiliated Hospital of Zhejiang Medical University,Hangzhou310003,China.

    
Objective To provide the clinical data and prognosis judgement,we observed the results andprogression of 11 cases of chronic radiation sickness due to external irradiation treatedwith thymopeptide.Methods The clinical symptoms,hematopoiesis,T lymphocyte percentage andchromosome aberration rate were used as the judgement indexes for recovery from thechronic radiation sickness.Results Thymopeptide treatment greatlyimproved the neurasthenic syndrome and increased the T lymphcytepercentage(P<0.05),which could enhance the patients' cellular immunity and cureulcerative stomatitis.But it did not increase the total count of white bloodcells(P>0.05) and decrease the chromosome aberration rate (p>0.05).The follow - up observation showed that in nineof 11 patients,improvement of neurasthenic syndrome occurred 3.5 years after they leftradiation work or diminished the exposure level.T lymphocyte percentage returned to normallevel after 2 years(P>0.05).5 to 8 years after,the total count of white blood cells andplatelets increased to their normal levels,and bone marrow hematopoiesis also restored tothe normal level.however,the chromosome aberration rate restoted to the normal level 10years after.Conclusion Accurding to our judgement criteria,the chronicradiation sickness from external radiation exposure can recover and thymopeptide is ahelpful and simple meams to treat it.

    
Key words Chronic radiation sickness Exteral irradiation thymopeptide Follow-up observationJudgement criteria

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