邱培才 陈积圣 邱培才(汕头市中心医院普外科 汕头 515031)；陈积圣(中山医科大学孙逸仙纪念医院 广州 510120) 中国普外基础与临床杂志 2000 0 7 4


    关键词：脾脏；脾切除术；抗肿瘤免疫；诱发性肝癌；动物实验 期刊 zgpwjcylczz 0 224-225 基础与实验研究 fur -->/literature/library/imagebase/imagebase03.asp?keyword=脾脏；脾切除术；抗肿瘤免疫；诱发性肝癌；动物实验


    

【摘要】 目的 探讨脾切除对诱发性肝癌大鼠抗肿瘤免疫功能的影响。方法 在大鼠诱发肝癌后的第2和第4个月时，检测脾切除组和对照组大鼠的NK细胞活性、TNF-α及淋巴细胞数的变化。结果 脾切除组大鼠NK细胞活性与对照组比较其差异具有显著性意义(P<0.05)，但外周血淋巴细胞计数、TNF-α水平与对照组比较差异无显著性性(P>0.05)。结论 脾切除后对诱发性肝癌大鼠的抗肿瘤免疫功能有一定的影响，表现为NK细胞活性持续降低，而淋巴细胞计数和细胞因子TNF-α经过一段时间后可恢复到正常水平，与对照组比较无明显差异。

    【中图分类号】 R730.3； R657.6 【文献标识码】 A

    【文章编号】 1007-9424(2000)04-0224-02

EFFECTS OF SPLENECTOMY ON ANTI-TUMOR IMMUNITY DURING THE INDUCTION OF HEPATOCELLULAR CARCINOMA IN RATS

QIU Pei-cai

    ( Department ofGeneral Surgery, The Central Hospital of Shantou, Shantou 515031 )

    CHEN Ji-sheng

【 Abstract 】 Objective To study the effect ofsplenectomy on the anti-tumor immunity in rats with induced hepatocellular carcinoma (HCC). Methods At thesecond and fourth month of the induced HCC, the NK cell activity, TNF- α level and total lymphcyte inblood were measured in the group of splenectomy and the control group. Results There were no different in thetotal lymphcyte and TNF- α in the blood in two groups, but there were significant difference in the NK cellactivity between the group of splenectomy and the control group (P < 0.05). Conclusion There are some change in the anti-tumor immunity aftersplenectomy in rats, in which NK cell activity is at low level continuously. TNF- α isn ′ t affected after the second month after splenectomy.

    

     【 Key words 】 Spleen Splenectomy Anti-tumor immunity Induced liver cancer Animal experimentation

脾脏是机体内最大的外周免疫器官 ......

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