许明智 杨玲玲 李秋香 许明智:原湖南医学大学精神卫生研究所研究生 现在新乡医学院二附院(453002)；杨玲玲 李秋香湖南医科大学精神卫生研究所 中国神经精神疾病杂志 1999 0 0 2


    关键词：精神分裂症；细胞因子；白细胞介素6；肿瘤坏死因子；可溶性白细胞介素2受体 期刊 zgsjjsjbzz 0 论著与学术交流 fur -->


    

【摘要】 目的 探讨细胞因子在精神分裂症病理生理机制中的作用。方法 采用酶联免疫吸附法(ELISA)检测60例精神分裂症和18例健康对照的血清IL-6、TNFα和SIL-2R水平。结果 精神分裂症患者血清IL-6(P<0.01)和TNFα(P<0.05)水平显著高于健康对照，且血清IL-6水平男性患者显著高于女性患者(P<0.05)，阳性家族史患者显著高于阴性家族史患者(P<0.05)，但精神分裂症患者血清SIL-2R水平与健康对照差异不显著(P>0.05)。结论 精神分裂症存在IL-6和TNFα介导的免疫功能异常，血清IL-6水平可能是其亚型的标志之一。

    The Study on Cytokines in Schizophrenic Patients ,XuMingzhi,Yang Lingling,Li Qiuxiang.Department of Psychiatry, Second Affiliated Hospital ofXinxiang Medical College, Jianshe Road,Xinxiang,HenanProvince.453002.Tel:0373-3386161-3013

    【Abstracts】Objective To explore the possiblepathophysiololgical mechanisms and the roles of the cytokines in schizophrenia. Methods Usingenzyme-linked immuno-sorbent assay(ELISA), serum levels of IL-6,TNFα and SIL-2R weremeasured in 60 schizophrenic patients and 18 healthy controls. Results SerumIL-6 and TNFα were significantly higher in schizophrenic patients than that in healthycontrols.In addition,serum IL-6 was significantly higher in male schizophrenic patientsthan in female ones,and in schizophrenic patients with a positive family history than inwhom without such history. Conclusions These results suggested thatschizophrenia may be resulted from immune disorder mediated through IL-6 and TNFα,andelevated serum IL-6 level may be a marker for a subtype of illness.

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