祖宏 祁芸云 赵玮 欧阳福珍 李湘燕 100034 北京医科大学第一临床医院老年内科 中国超声医学杂志 2000 0 16 12


    关键词：血管超声；高血压；内皮舒张功能 期刊 zgcsyxzz 0 903-906 临床研究 fur -->


    

摘 要 目的及方法：本文应用血管超声技术对28名原发性高血压患者(Ⅰ期17例，Ⅱ期11例)和13名正常人前臂动脉血管内皮依赖性舒张功能进行了定量研究。结果：高血压Ⅰ组及Ⅱ组患者反应性充血后血流介导的血管扩张(FMD)均较正常人明显下降(P<0.05，P<0.01)。高血压Ⅰ组与Ⅱ组患者充血反应(RH)均较正常人明显减少(P<0.05)，而平滑肌介导的血管扩张功能(GNT-MD)在三组中无差异。正常人给予左旋精氨酸(L-Arg)后，FMD及RH增加，与用药前相比有明显差异(P<0.05)，平滑肌介导的血管扩张功能(GNT-MD)在用药前后无差异，而两组高血压患者给予L-Arg后，FMD，RH及GNT-MD在用药前后均无差异。结论：无创性血管超声检查血管内皮功能的方法在临床应用中是可行的。

    

Studiesof Vascular Endothelium Function in Essential Hypertension

Zu Hong Qi Yunyun Zhao Wei

    The First Hospital of Beijing Medical University Beijing 100034 China

ABSTRACT Objective and Methods：We used vascularultrasound to observe relaxing factors derived from the brachial artery endothelium tomediate relaxation of vasculature,the function changed by infusing L-Arg in essential hypertension.Twenty-eight patients with essential hypertension and thirteen normalsubjects were recruited for the study.The hypertension group was divided into two groups,(Ⅰ)phaseone of hypertension,17 cases.(Ⅱ)phase two of hypertension,11 cases.Results:Flow-mediated dilatation(FMD) and reactive hyperemia(RH) were decreased in essential hypertension groupscompared with those of control(P<0.05 ......