李小军 白艳婷 田伏洲 刘晓波 尹致良 成都军区总医院普外中心(成都 610083) 中国普外基础与临床杂志 1999 0 6 5


    关键词：新城疫病毒；热固化瘤苗；荷瘤小鼠 期刊 zgpwjcylczz 0 基础与实验研究 fur -->


    

摘要 为探讨新城疫病毒(简称NDV)联合热固化瘤苗对小鼠肿瘤的抑瘤作用和免疫调节作用，实验检测了荷瘤小鼠的抑瘤率和细胞免疫功能。实验将接种上SP2/0及H22瘤细胞的荷瘤小鼠分为单纯NDV治疗组(实验Ⅰ组)和NDV+热固化瘤苗治疗组(实验Ⅱ组)。结果显示：实验Ⅰ组与实验Ⅱ组抑瘤率分别为24.8%和41.1%，两组的平均瘤重明显小于对照组，且实验Ⅰ组和实验Ⅱ组在不同时段的自然杀伤(NK)细胞活性均高于对照组(P<0.01)，实验Ⅱ组的抑瘤率和NK细胞活性比实验Ⅰ组更高。提示NDV联合热固化瘤苗对荷瘤小鼠的抑瘤作用和增强NK细胞活性均比单独应用NDV的效果好。

STUDY ON ANTI-TUMOR ROLE OF NEWCASTLE DISEASEVIRUS COMBINED THERMIC SOLIDIFIED TUMOR VACCINE IN RATS

Li Xiaojun, Bai Yanting, Tian Fuzhou, et al.

    PLA Center of General Surgery, General Hospital of Chengdu Command, Chengdu 610083

Abstract In this study, the roleof newcastle disease virus (NDV) combined thermic solidified tumor vaccine in inhibitinggrowth of tumor and immune control was investigated, and rate of inhibiting tumor andcellular immunity were measured. The results showed that rate of inhibiting tumor inexperimental group Ⅰ and Ⅱ were 24.8% and 41.1% respectively; average weight of tumorwas significantly lower in both experimental groups than in control group, and activity ofnatural killing (NK) cells in experimental groups was higher than that in control group (P<0.01).This suggests that NDV combined thermic solidified tumor vaccine can inhibit growth oftumor and improve activity of NK cells, and their effects are better than that of NDV.

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