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地龙促进痔术后创面愈合的实验和临床研究
http://www.100md.com 《中国普外基础与临床杂志》 2000年第1期
地龙|创伤愈合|痔|外科|动物模型,关键词:,.
地龙促进痔术后创面愈合的实验和临床研究

     王沛 曾耀辉 李东冰 赵雅茹 钱静仁 陈希琳 赵玉琴 吴佐周 王沛(北京中医药大学 北京 100070);曾耀辉(清华大学生物系 北京 100081);李东冰 赵雅茹 钱静仁 陈希琳 赵玉琴 吴佐周(北京市二龙路医院 北京 100032) 中国普外基础与临床杂志 2000 0 7 1


    关键词:地龙;创伤愈合;痔;外科;动物模型 期刊 zgpwjcylczz 0 6-9 基础与实验研究 fur -->


    

摘 要:目的 探讨地龙对痔术后创面愈合的影响。方法 将人工养殖的鲜地龙制成的溶液喷洒于实验动物及混合痔手术后患者的创面,观察其创面的炎症情况、愈合情况以及各实验观测指标的变化,并与对照组进行比较。结果 动物实验中,地龙能抑制金黄色葡萄球菌、大肠杆菌及绿脓杆菌的生长;实验组创面愈合时间较对照组提前了4天;第4、7天实验组动物创面的毛细血管数、血管腔内皮细胞数及间质成纤维细胞数均较对照组明显增多,上皮细胞分裂象也高于对照组,第4天的间皮细胞分裂象也高于对照组;自第3天始创面愈合及肉芽充填速度实验组明显快于对照组。临床实验中 ,实验组创面愈合时间平均16.5天,较对照组(21.2天)明显缩短;用药后3天内表皮生长速度明显快于对照组,且无创面感染及肉芽过度增生。结论 地龙能抑制创面的炎症反应,并促进其愈合;该制剂价廉,易保存,可用于痔术后创面以促进其愈合。

    分类号: R657.1+ 8;R282.74 文献标识码: A

    文章编号: 1007-9424(2000)01-0006-04

EXPERIMENTAL AND CLINICAL STUDY ON LUMBRICUS ACCELERATING POSTOPERATIVE WOUND HEALING AFTER HEMORROIDECTOMY

LI Dong-bing

    (
Erlong Road Hospital of Beijing City,Beijing 100032)

    WANG Pei,ZENG Yao-hui,et al.

Abstract:Objective To probe the effects of lumbricus on wound healing after hemorroidectomy.Methods After the solution made from artificial grown lumbricus was sprung to the wound of animal and patient after hemorroidectomy,the wound inflammation,wound healing and changes of laboratory determinations were observed and compared to those of the control group.Results In animal study,lumbricus could inhibit the growth of staphylococci,bacillus coli and bacillus aeruginosus.The time of wound healing in experimental group was 4 days shorter than that in control group.At 4d and 7 day the numbers of the capillary,blood vessel endodermis and desmohemoblast desmocyte and splitting epithelium of trial group were much more than those of control group.At 4d the trial group′s numbers of splitting mesenchymal cell were much more than that of control group.From 3d on the wound healing and granulation filling of experimental group were much quicker than those of control group.In clinical study,the time of wound healing of trial group ( a mean of 16.5 days) was shorter than that of control group (21.2 days).From 3d on,the epidermis′growth speed of the trial patients was much quicker than that of control group and was without wound infection and granulation overproliferation.Conclusion Lumbricus can inhibit wound inflammation response and accelerate wound healing.Lumbricus is inexpensive and easily preserved,and could be used on the wound after hemorroidectomy to accelerate wound healing.

    Key words Lumbricus Wound healing Hemorrhoid Surgery Animal model▲

痔疮是临床多发病 ......


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