黄显凯 韩本立 黄显凯 第三军医大学大坪医院普外科(重庆 400042)；韩本立 第三军医大学西南医院肝胆中心 中国普外基础与临床杂志 1999 0 6 5


    关键词：胆管炎；肝微循环；细胞间粘附分子-1；E-选择素 期刊 zgpwjcylczz 0 基础与实验研究 fur -->


    

摘要 为探讨细胞间粘附分子-1(ICAM-1)和E-选择素(E-selectin)在急性胆管炎肝微循环变化中的作用，对急性胆管炎时肝脏组织学、肝脏血流量及肝组织伊文思蓝(EB)含量的变化，以及ICAM-1和E-选择素单抗预处理对以上变化的影响进行了观察。结果：急性胆管炎时肝窦内皮细胞及肝细胞出现变性和结构破坏，肝窦及肝细胞周围多形核粒细胞(PMN)数量显著增多，肝微血管血流量明显减少，肝组织EB含量显著增高，肝窦通透性增高；而抗ICAM-1及E-选择素单抗预处理使以上损害均明显减轻。由此表明，ICAM-1及E-选择素在肝脏微循环障碍的发生发展中起重要作用。

THE EFFECT OF INTERCELLULAR ADHESIVENESSMOLECULE-1， E-SELECTIN ON HEPATIC MICROCIRCULATION IN ACUTE CHOLANGITIS

Huang Xiankai, Han Benli.

    Department of General Surgery, Daping Hospital, Third Military Medical University,Chongqing 400042

Abstract To evaluate the effect ofintercellular adhesiveness molecule-1 (ICAM-1), E-selectin on hepatic microcirculation inacute cholangitis. The Changes of hepatic tissue, content of blood flow and Evan′s blue (EB) in hepatic tissue in acute cholangitis were determinated. Results: The number of PMNin hepatic tissue and sinusin increased, degenaration and necrosis of the hepatic cellsand hepatic sinusoidal endothelial cells and content of blood flow in liver were reduced,and content of EB in hepatic tissue increased remarkbly in the rats with acute cholangitis. Pretreatment of anti ICAM-1 and E-selectin mAb reduced the damage of hepaticmicrocirculation. Conclusion: ICAM-1 and E-selectin may play an important role in damageto hepatic microcirculation in acute cholangitis.

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