关键词：胆管肿瘤；癌基因；基因表达
李哲夫 史光军 综述 胡义利 审校
【摘要】 目的 寻找对胆管癌早期诊断和判断其预后有意义的指标。方法 复习国内外文献有关胆管癌组织中各种基因的改变及其临床意义。结果 胆管癌组织中存在多种基因的点突变、缺失和过度表达，其中以K-ras基因的研究最为深入。结论 K-ras基因点突变的检测将有助于胆管癌的早期发现和判断其预后。
【中图分类号】 R735.8 【文献标识码】 A
【文章编号】 1007-9424(2000)02-0131-03
GENE EXPRESSION IN CHOLANGIOCARCINOMA
AND ITS CLINICAL SIGNIFICANCE
LI Zhe-fu, SHI Guang-jun, HU Yi-li.
( Department ofHepatobiliary Surgery, Qingdao Municipal Hospital, Qingdao 266011 )
【 Abstract 】 Objective To search for the significantearly diagnostic and prognostic indicators in cholangiocarcinoma. Methods Literatures about the variationof various kinds of genes in cholangiocarcinoma and their clinical significances werereviewed. Results Thereare several genes mutation, deletion and overexpression in cholangiocarcinoma, K-ras genewas most deeply investigated. Conclusion K-ras mutation detection may be of help in the earlyfinding and prognosis of cholangiocarcinoma.
【 Key words 】 Cholangioneoplasm Oncogene Gene expression ▲
胆管癌一旦发现多为晚期 ......
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