陈燕昌 陈大良 殷凤峙 福建医科大学附属协和医院普外科(福州 350001) 中国普外基础与临床杂志 1999 0 6 5


    关键词：甲状腺肿瘤；表皮生长因子受体；免疫组织化学 期刊 zgpwjcylczz 0 临床研究 fur -->


    

摘要 为了解甲状腺癌中表皮生长因子受体(EGFR)的表达意义，应用免疫组化方法检测了81例甲状腺癌中EGFR的表达，并与甲状腺腺瘤和癌旁正常甲状腺组织相比较。结果：甲状腺癌中45例EGFR表达阳性(55.6%)，而甲状腺腺瘤及癌旁正常甲状腺组织中均未见EGFR表达(P<0.01)。EGFR表达阳性率在甲状腺癌的病理类型、临床分期、浸润程度及淋巴结转移诸因素间的差异均无统计学意义(P>0.05)，且与患者生存率亦无显著相关(P>0.05)。本实验结果提示：EGFR过度表达与甲状腺癌细胞自主性生长和恶性表型有关，但不能作为评估其生物学行为和预后的有效指标。

EXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR INHUMAN THYROID CARCINOMAS

Chen Yanchang, Chen Daliang, Yin Fengshi.

    Department of General Surgery, Affiliated Union Hospital, Fujian Medical University,Fuzhou 350001

Abstract To investigate thesignificance of epidermal growth factor receptor (EGFR) in thyroid carcinoma, theexpression of EGFR in 81 samples of thyroid carcinoma were determined byimmunohistochemical SP method and comparison among thyroid carcinoma, thyroid adenomas andnormal thyroid tissue adjacent to the cancer were made. The results showed: EGFRexpression was positive in 45 cases (55.6%) of thyroid carcinoma with no positiveexpression either in thyroid adenomas or normal thyroid tissue adjacent to the cancer (P<0.01).There were no statistical differences between EGFR positive rate and thyroid carcinomatouspathological type, clinical stage, depth of invasion, lymph node metastasis or patients′postoperative survival time (P>0.05). This data suggests that expression of EGFR inthyroid carcinoma is associated with its autonomous growth and malignant phenotype, but itis probably not a useful index for assessing the biological behavious and prognosis ofthyroid carcinoma.

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