汪丽燕,乔镇,关景明, 吕丽燕, 张春燕,哈尔滨医科大学附属第二医院消化内科 黑龙江省哈尔滨市 150086

    汪丽燕,女,1976-12-27生,黑龙江省哈尔滨市,汉族.2002年哈尔滨医科大学硕士.

    黑龙江省科技厅攻关课题,No. GB01C12403

    通讯作者:关景明,150086, 黑龙江省哈尔滨市,哈尔滨医科大学附属第二医院消化内科. 168wangliyan@163.com

    电话: 0451-86605143

    收稿日期:2005-04-04 接受日期:2005-04-09

    Roles of MMP-2, MMP-9 and their inhibitors inprogression of colorectal neoplasm into colorectal carcinoma

    Li-Yan Wang, Zhen Qiao, Jing-Ming Guan, Li-Yan Lv, Chun-Yan Zhang

    Li-Yan Wang, ZhenQiao, Jing-Ming Guan, Li-Yan Lv, Chun-Yan Zhang, the Second AffiliatedHospital of Harbin Medical University, Harbin 150086, HeilongjiangProvince, China

    Supported by the Fund from Science and Technology Department ofHeilongjiang Province, No.GB01C12403

    Correspondence to: Jing-Ming Guan, Department of Gastroenterology,the Second Affiliated Hospital of Harbin Medical University, Harbin150086, Heilongjiang Province, China. 168wangliyan@163.com

    Received: 2005-04-04 Accepted:2005-04-09

    Abstract

    AIM: To investigate the expression of matrix metalloproteinase-2(MMP-2), MMP-9, tissue inhibitor of metalloproteinase-2 (TIMP-2) andTIMP-1 colorectal mucous tissues with different types, and to explore theclinical significance of MMP-2/TIMP-2, MMP-9/TIMP-1 in the progression ofcolorectal neoplasm into colorectal carcinoma. ......