消炎痛和阿斯匹林对C57BL/6和Balb/c小鼠胃酸分泌的效应
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王昌成
消炎痛;阿斯匹林;C57BL,6;Balb,c;胃酸,王昌成,通讯作者,:,Effectsofindomethacinandasp
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王昌成 , 淮安市第二人民医院消化科 江苏省淮安市 223002
王昌成, 男, 1964-03-06生, 江苏省泗阳县人, 汉族, 1991年上海第二医科大学消化内科硕士, 主任医师, 主要从事消化系疾病的基础和临床研究.
通讯作者 : 王昌成, 223002, 江苏省淮安市第二人民医院消化科.
wangchangcheng8001@163.com
收稿日期: 2005-04-26 接受日期: 2005-05-15
Effects of indomethacin and aspirin on gastric acid secretion in C57BL/6 and Balb/c mice
Chang-Cheng Wang
Chang-Cheng Wang, Department of Gastroenterology, Huaian Second People's Hospital, Huaian 223002, Jiangsu Province, China
Correspondence to: Dr. Chang-Cheng Wang, Department of Gastroe-nterology, Huaian Second People's Hospital, Huaian 223002, Jiangsu Province, China. wangchangcheng8001@163.com
Received: 2005-04-26 Accepted: 2005-05-15
Abstract
AIM: To investigate the effects of indomethacin and aspirin on the gastric acid secretion and gastric lesions in C57BL/6 and Balb/c mice.
METHODS: The total acid volume (mL), acidity ([H+] mmol/L) and total 3-hour acid output (mmol/h) were determined after intraperitoneal administration of indomethacin and aspirin in the two different strains of mice by pylorus ligation technique and the gastric lesions were evaluated by Lanza score. Histamine-stimulated [14C]-aminopyrine accumulation was used to determine the changes of gastric acid secretion in the two strains of mice in vitro.
RESULTS: In baseline, total acid volume and total 3-hour acid output were significantly different between C57BL/6 and Balb/c mice (0 ......
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