【摘要】恶性肿瘤的淋巴道转移和血行转移机制及抗肿瘤淋巴道转移的治疗是目前的研究热点之一，有研究表明，恶性肿瘤发生淋巴管转移与肿瘤周围淋巴管密度直接相关。血管内皮生长因子家族(VEGF)中对不同恶性肿瘤的转移方式起着不用的作用。VEGF-A，VEGF-B与微小血管生成有关，参与恶性肿瘤的血行转移，VEGF-C和VEGF-D被学者称为淋巴管生成因子，与肿瘤的淋巴道转移密切相关并可判断肿瘤的预后。本文对于VEGF家族和口腔鳞癌微淋巴管生成的现状和发展进行综述。

    【关键词】淋巴结;转移;VEGF

    The VEGF-C，-D and VEGFR3effect in lymph node metastasis of oral squamous cell carcinoma

    QU Xing-zhou，ZHANG Chen-ping.The Affiliated Ninth People's Hospital，Department of Oral and Maxillofacial Surgery，Shanghai Second Medical University，Shanghai200011，China

    【Abstract】 The mechanism and inhibition of lymph node metastasis of malignant tumor are one of the research hot points.Many studies indicating vascular endothelial growth factor-C(VEGF-C)and D(VEGF-D)were named by growth factors and closely associated with lymph node metastasis.This article mainly reviewed the family of VEGF and the difference about their expressions in squamous cell carcinoma and adnocarcinoma of oral cavity.

    【Key words】 lymph node;metastasis;VEGF

    恶性肿瘤的转移主要有以下四种:(1)直接侵犯;(2)种植播散;(3)淋巴转移;(4)血行转移 ......