【摘要】

    目的 探讨血清脂蛋白(a)[LP(a)]水平对冠状动脉支架置入术后6个月心血管事件和再狭窄的预测价值。

    方法 术前测定88例冠状动脉支架置入术患者基础的LP(a)水平，随机分为LP(a)<300mg/L和LP(a)≥300mg/L两组，随访术后6个月内心血管事件(心肌梗死和死亡)发生率和支架内再狭窄等情况。

    结果 (1)基础血清LP(a)不稳定型心绞痛组与稳定型心绞痛组相比明显升高(P<0.01)；(2)在LP(a)升高组和正常组，在冠状动脉病变的特点、PTCA和支架所用的球囊、支架长短、大小、最大扩张压力及扩张时间等方面差异均无显著性(P>0.05)；(3)术后6个月主要心血管不良事件LP(a)≥300mg/L组和LP(a)<300mg/L相比有增加趋势，但差异无显著性(P>0.05)；(4)术后6个月内支架内再狭窄发生率在LP(a)≥300mg/L、不稳定型心绞痛组与LP(a)<300mg/L、稳定型心绞痛组相比明显升高。

    结论 基础血清LP(a)水平是冠状动脉支架置入术后6个月心血管主要不良事件和支架再狭窄发生率的一个重要预测指标。

    【关键词】 脂蛋白(a)；支架；血管成形术；再狭窄；心血管事件

    The value of preprocedural serum levels of LP(a) in predicting cardiovascular events and restenosis after coronary stent implantation

    LIU Xin-bing,CAO Guo-liang,FENG Liu-liu,et al.Department of Cardiology,Shidong Hospital,Shanghai 200843,China

    【Abstract】

    Objective To investigate whether the cardiovascular events in 6 months after coronary stent impantation could be predicted by baseline levels of lipoprotein(a)[LP(a)].

    Methods We measured LP(a) for 88 patients with coronary stent implantation.In which,there were 40 patients with stable angina pectoris,48 patients with unstable angina pectoris.According to the level of LP(a),the patients were divided into two groups;LP(a)<300mg/L group and LP(a)≥300mg/L group.The cardiovascular events and stent restenosis were carefully observed and recorded in 6 months after the procedures. ......