【摘要】

    目的 探讨米非司酮联合甲氨蝶呤治疗异位妊娠的效果。

    方法 78例输卵管妊娠患者随机分为A、B两组，A组42例给予米非司酮，3次/d，口服，每次50mg，连续3天，同时给予甲氨蝶呤60mg 一次性肌肉注射。B组36例，给予甲氨蝶呤60mg一次性肌肉注射。定期检测血β-HCG、血常规、肝、肾、凝血功能、B超。

    结果 米非司酮联合甲氨蝶呤治疗异位妊娠成功率为88.09%，明显高于对照组。治疗效果与用药方案及治疗前血β-HCG水平有关。

    结论 米非司酮联合甲氨蝶呤治疗异位妊娠安全有效，早期诊断、严格掌握适应证是治疗成功的关键。

    关键词 异位妊娠 米非司酮 甲氨蝶呤

    Combination of mifepristone and methotrexate for treatment of ectopic pregnancy

    Wang Dongmei, Liu Ronghua,Zhang Youzhong The Qi-Lu Hospital of Shandong University,Jinan 250012.

    【Abstract】

    Objective To investigate the efficacy of mifepristone and methotrexate for treatment of ectopic pregnancy.

    Methods 78 cases of tubal pregnancy were divided into A and B groups. Group A with 42 cases was treated by mifepristone and methotrexate, mifepristone 50mg orally three times one day, for three days, methotrexate 60mg intramuscular injection only once. Group B with 36 cases was treated by methotrexate 60mg intramuscular injection only once. The serum β-hCG, the blood routine, the function of liver, kidney and coagulation , B ultrasound were monitored regularly. ......