【摘要】 目的 探讨一种内皮素受体拮抗剂—阿魏酸钠微量泵持续静脉注射治疗新生儿肺动脉高压的疗效和不良反应。 方法 对64例肺动脉高压的新生儿在呼吸机械通气的情况下同时用微量泵持续静脉注射阿魏酸钠，阿魏酸钠微量泵静脉注射的速度由5μg/(kg·min)开始，在保证体循环血压的基础上可以逐渐加量至10μg/(kg·min)，直至20μg/(kg·min)。治疗时用重症监护仪监测患儿血压、心率、血氧饱和度，以压差法用超声多普勒监测肺动脉的压力等指标。 结果 阿魏酸钠微量泵持续静脉注射后患儿的肺动脉压力显著下降(P<0.01)，PaO 2 、经皮测血氧饱和度(TcSaO 2 )、平均动脉压(MAP)等指标改善均有显著性意义(P<0.01)，血压、心率、凝血功能等改变无明显差异。 结论 阿魏酸钠微量泵持续静脉注射治疗新生儿肺血管平滑肌痉挛所致的肺动脉高压有显著的疗效，且未见明显副作用。

    关键词 阿魏酸钠 新生儿肺动脉高压

    Continuously injecting tetramethylpyrazine by mini pump in treatment of neonatal pulmonary arterial hypertension

    Liang Zhicheng，Guo Tiejun，Pan Cuiqi

    Maternal and Infant Health Hospital of Zengcheng，Guangdong511300.

    【Abstract】 Objective The anticogant to the endotheliotoxin receptor is a promising drug to treat with the pulmonary arterial hypertension therotically.But in our country there was few systemical clinical trial about the drug used in the disease.We study the curative effect and the side effect of an anticogant to the endotheliotoxin receptor-Tetramethylpyrazine on the pulmonary arterial hypertension.Methods The64newborn patients were continually main line the tetramethylpyrazine by the mini pump and stimutaneously treated with the respiratory machine.The injec-tion speed was controlled from5μg/kg·min to10μg/kg·min ......