【摘要】 目的 分析早产中宫内感染的相关因素和致病菌，探讨抗生素在早产治疗中的价值。 方法 研究2003年1月～2004年12月187例单胎妊娠的自发早产病例，行胎盘胎膜病理检查及细菌培养试验，其中59例诊断为宫内感染。 结果 早产中宫内感染的发生率为31.5%，其相关因素为胎膜早破、自然流产和早产病史、早产孕周小于34周、产前用糖皮质激素治疗，主要的致病菌为链球菌、大肠埃希氏菌和凝固酶阴性葡萄球菌。结论在有宫内感染的高危因素的早产治疗中应用抗生素有助于延长孕周和减少母儿发病率。

    【关键词】 早产;胎膜早破;宫内感染;治疗

    The effect of antibiotic therapy on preterm parturition

    CAI Jian，HUANG Shun-ying，YANG Jian-bo，et al.

    The First Affiliated Hospital of Sun Yat-sen University，Guangzhou510080，China

    【Abstract】 Objective This study aims to determine the risk factors and bacterial pathogens of intrauterine infec-tion in the preterm delivery and discuss the antibiotic therapy on preterm parturition.Methods This prospective study was conducted over2years from January2003to December2004，included187singleton spontaneous preterm deliveries.59cases were diagnosed intrauterine infection by pathology and germiculture of placenta and membranes.Results The incidence of intrauterine infection of preterm delivery was31.5%.The risk factors of intrauterine in-fection were preterm rupture of membranes ......