【摘要】 目的 探讨参附注射液(SFI)对全麻苏醒期通气功能的影响及其机制。 方法 86例ASAⅠ～Ⅱ级静吸复合麻醉2～4h的择期普外手术患者，手术结束后未醒、未有自主呼吸进入麻醉恢复室(PACU)进行机械通气。随机分两组，每组43例。观察组入室后静脉滴注SFI1ml/kg加入乳酸钠林格液共100ml，对照组入室后以等量乳酸钠林格液100ml代替SFI静脉滴注。监测用药前机控呼吸气道内压力值、停机时气道内压力值、潮气量、分钟通气量及用药前后动脉血气分析(pH、PaCO 2 、PaO 2 /FiO 2 )及血氧饱和度。于用药前(T 0 )、用药后5min(T 1 )、15min(T 2 )、45min(T 3 )抽静脉血测定血浆β-内啡肽(β-EP)。 结果 用药后气道内压力值比用药前降低(P<0.05)，也低于同时段的对照组(P<0.05);潮气量比对照组大(P<0.01);氧合指数(PaO 2 /FiO 2 )改善(P<0.05);PaCO 2 停机后均有所上升，但两者差异无显著性;pH变化在治疗满意范围，观察组更接近正常;观察组血浆β-EP T 1 比T 0 上升，T 2 更明显(P<0.01);对照组则下降，T 2 与观察组T 2 相比下降明显(P<0.001)。 结论 SFI用于催醒，能改善通气功能和氧合指数，其机制可能与血浆β-EP升高有关。

    【关键词】 参附注射液;静吸复合麻醉;通气功能;β-内啡肽

    Exploration on the effect and mechanism of Shenfu injection on respiratory func-tion of resuscitation after general anesthesia

    HUANGYan-hong，WANG Shao-li.

    Yuebei Peoples Hospital，Shaoguan512026，China

    【Abstract】 Objective To investigate the effect and mechanism of Shenfu injection(SFI)on respiratory function of resuscitation after general anesthesia.Methods Eighty-six adult patients who received selective abdominal surgery with general anesthesia for2～5hrs and ASAⅠ～Ⅱgrade were sent into the post anesthesia care unit(PACU)and given mechanical ventilation after surgery with no mind and self respiration.They were randomly divided into two groups ......