【摘要】 目的 检测三叉神经痛患者脑脊液和血清中SOD含量，探讨三叉神经痛的发病机制。方法 三叉神经痛患者31例，在行经皮穿刺三叉神经节射频控温热凝术中抽取脑脊液，同时抽取肘静脉血，分别检测其SOD含量。对照组为33例非神经系统疾病的腰麻手术患者，抽取脑脊液及肘静脉血送检，测定SOD含量。结果 三叉神经痛组脑脊液SOD含量非常显著高于对照组(P<0.01)，而血清中SOD含量与对照组比较差异无显著性；三叉神经痛组脑脊液SOD含量显著高于血清SOD含量。结论 SOD含量升高是机体中内源性防御功能的反应，三叉神经节胞体病灶及神经根处脱髓鞘病变形成“短路”可能与原发性三叉神经痛发病机制有关。

    【关键词】 三叉神经痛；超氧化物歧化酶；病因学

    Clinical significance of detecting SOD content in blood and CSF in trifacial neuralgia patients

    WANG Jian-xiu.

    Department of Anesthesiology,Zibo Central Hospital,Zibo 255036,China

    【Abstract】 Objective To detect the SOD content in blood and CSF in trifacial neuralgia patients,and get a deep study about its pathogenetic mechanism.Methods 64 patients were studied,in which 31 cases were trifacial neuralgia patients who would be performed by percutaneous radiofrequency thermorhizotomy,33 cases were non-nervous system patients who would be performed by lumbar anesthesia before operations.The SOD content in blood and CSF were detected in all of the patients.Results The SOD content in CSF in trifacial neuralgia patients group was obviously higher than that in the non-nervous system patients group(P<0.01),the SOD content in blood has no significant difference between the two groups,and the SOD content in CSF of trifacial neuralgia patients group was higher than that in blood of the same group.Conclusion The advancing of SOD content in CSF is a reaction of endogenetic defense function,trigeminal fibers demyelination results in direct contact to the illness in soma of trigeminal ganglion might be the main pathogenesis of original trifacial neuralgia. ......