细甘草甜素下调基质金属蛋白酶组织抑制因子-1基因的表达
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王巧侠，成 军，郭 江，李文凡，魏红山
甘草甜素;基质金属蛋白酶组织抑制因子-1;抗纤维化,王巧侠，,军,郭江,魏红山，,李文凡,王巧侠,通讯作者：,Glycyrrhizindo
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王巧侠，兰州大学临床医学院 甘肃省兰州市 730000
成军, 郭江, 魏红山，北京地坛医院传染病研究所 北京市 100011
李文凡, 甘肃省人民医院消化科 甘肃省兰州市 730000
王巧侠, 女, 1975-03-29生, 陕西省西安市人, 汉族, 住院医师, 兰州大学2003级传染病学硕士研究生, 主要从事慢性肝脏疾病发病机制的研究.
国家自然科学基金攻关项目，No. C03011402，No. C30070689
军队九五科技攻关项目，No. 98D063
军队回国留学人员启动基金项目，No. 98H038
军队十五科技攻关青年基金项目，No. 01Q138
军队十五科技攻关面上项目，No. 01MB135
通讯作者：成军, 100011, 北京市东城区安外大街地坛公园13号, 北京地坛医院传染病研究所. cj@genetherapy.com.cn
电话：010-64481639 传真：010-64281540
收稿日期：2005-07-05 接受日期：2005-07-08
Glycyrrhizin down-regulates expression of tissue inhibitor of metalloproteinases-1
Qiao-Xia Wang, Jun Cheng, Jiang Guo, Wen-Fan Li, Hong-Shan Wei
Qiao-Xia Wang, Lanzhou University, Lanzhou 730000, Gansu Province, China
Jun Cheng, Jiang Guo, Hong-Shan Wei, Institute of Infectious Diseases, Ditan Hospital, Beijing 100011, China
Wen-Fan Li, Department of Gastroenterology, The People’s Hospital of Gansu Province, Lanzhou 730000, Gansu Province, China
Supported by National Natural Science Foundation, No. C03011402, No. C30070689; Returned Scholarship of General Logistics Department of Chinese PLA, No. 98H038; the Key Technology Research and Development Program of Chinese PLA during the 9th Five-Year Plan Period, No. 98D063; the Key Technology Research and Development Program of Chinese PLA for Distinguished Young Scholars during the 10th Five-Year Plan Period, No. 01Q138; and the Scientific Research Program of Chinese PLA during the 10th Five-Year Plan Period, No. 01MB135
Correspondence to: Dr. Jun Cheng, Anwai Street, Dongcheng District, Institute of Infectious Diseases, 13 Ditan Park, Ditan Hospital, Beijing 100011, China. cj@genetherapy.com.cn
Received: 2005-07-05 Accepted: 2005-07-08
Abstract
AIM: To investigate the regulatory effect of glycyrrhizin on the tissue inhibitor of metalloproteinases-1(TIMP-1) expression and to explore its anti-fibrosis mechanism ......
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