肝病患者 IgA 和 sIgA 含量变化的临床意义
http://www.100md.com 刘冬妍, 刘 沛
刘冬妍, 刘沛, 中国医科大学附属第二医院传染科 辽宁省沈阳市 110004
通讯作者：刘沛, 110004，辽宁省沈阳市三好街36号，中国医科大学附属第二医院传染科. email@example.com
Changes of IgA and sIgA and its clinical significant in hepatic diseases
Dong-Yan Liu, Pei Liu
Dong-Yan Liu, Pei Liu, Department of Infectious Diseases, the Second Affiliated of China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to: Pei Liu, Department of Infectious Diseases, the Second Affiliated Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, Liaoning Province,China. firstname.lastname@example.org
Received: 2005-06-30 Accepted: 2005-07-15
AIM: To investigate the values of IgA and sIgA detection in the clinical diagnosis of hepatic diseases.
METHODS: Patients with acute hepatitis (AH, n = 35), chronic severe hepatitis (CSH, n = 9), chronic hepatitis (CH, n = 67) and liver cirrhosis (LC, n = 57) were involved. The level of IgA was assayed by rate nephelometry, and the level of sIgA was detected by radioimmunoassay.
RESULTS: The levels of fecal IgA and sIgA were notably elevated in patients with AH, CSH, CH and LC as compared with those in the controls (IgA: 100±47, 251±178, 80±24, 145±164 mg/L vs <67 mg/L, P <0.01; sIgA: 88±96, 326±237, 88±121, 104±109 mg/L vs 13±10 mg/L, P <0.01). IgA was positively correlated with sIgA(r = 0.4371, P <0.01). The levels of serum IgA and sIgA were markedly increased in patients with AH, CSH, CH and LC as compared with those in the controls (IgA: 3.1±1.1, 3.4±1.8, 3.3±1.7, 4.9±3.3 g/L vs 1.6±0.2 g/L, P <0.01; sIgA: 31.1±25.8, 80.3±25.4, 30.5±24.1, 50.0±20.5 µg/L vs 23.4±8.2 µg/L, P <0.01 or P <0.05). The fecal IgA and sIgA were not correlated with serum IgA and sIgA, and serum IgA was not correlated with serum sIgA (P >0.05). In patients with CH, CSH and LC, serum sIgA was significantly correlated with alkaline phosphatase (r = 0.523 0, P <0.01) and total bilirubin (r = 0.4 581, P <0.01). In patients with AH, serum sIgA level was correlated with alanine aminotransferase (r = 0.4 692, P <0.01), total bilirubin (r = 0.4 265, P <0.01).
CONCLUSION: The detection of IgA and sIgA can be used in the clinical diagnosis of hepatic diseases.
Key Words: IgA; sIgA; Hepatic disease
Liu DY, Liu P. Changes of IgA and sIgA and its clinical significant in hepatic diseases. Shijie Huaren Xiaohua Zazhi 2005;13(18):2275-2277
结果：肝脏患者粪便IgA，sIgA均显著高于正常对照组 (IgA: 100±47, 251±178, 80±24, 145±164 mg/L vs <67 mg/L, P<0.01; sIgA: 88±96, 326±237, 88±121, 104±109 mg/L vs 13±10 mg/L, P<0.01)，IgA和sIgA呈显著正相关 (r = 0.4371, P<0.01).血清中IgA和sIgA显著高于正常对照组( IgA: 3 ......