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肝病患者 IgA 和 sIgA 含量变化的临床意义
http://www.100md.com 刘冬妍, 刘 沛
IgA;sIgA;肝病,肝病患者IgA和sIgA含量变化的临床意义,刘冬妍,刘沛,通讯作者:,电话:,收稿日期:,接受日期:,ChangesofIgAandsIgAanditsclinicalsig
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     刘冬妍, 刘沛, 中国医科大学附属第二医院传染科 辽宁省沈阳市 110004

    通讯作者:刘沛, 110004,辽宁省沈阳市三好街36号,中国医科大学附属第二医院传染科. syliupei2003@yahoo.com.cn

    电话:024-83956962

    收稿日期:2005-06-30 接受日期:2005-07-15

    Changes of IgA and sIgA and its clinical significant in hepatic diseases

    Dong-Yan Liu, Pei Liu

    Dong-Yan Liu, Pei Liu, Department of Infectious Diseases, the Second Affiliated of China Medical University, Shenyang 110004, Liaoning Province, China

    Correspondence to: Pei Liu, Department of Infectious Diseases, the Second Affiliated Hospital of China Medical University, 36 Sanhao Street, Shenyang 110004, Liaoning Province,China. syliupei2003@yahoo.com.cn

    Received: 2005-06-30 Accepted: 2005-07-15

    Abstract

    AIM: To investigate the values of IgA and sIgA detection in the clinical diagnosis of hepatic diseases.

    METHODS: Patients with acute hepatitis (AH, n = 35), chronic severe hepatitis (CSH, n = 9), chronic hepatitis (CH, n = 67) and liver cirrhosis (LC, n = 57) were involved. The level of IgA was assayed by rate nephelometry, and the level of sIgA was detected by radioimmunoassay.

    RESULTS: The levels of fecal IgA and sIgA were notably elevated in patients with AH, CSH, CH and LC as compared with those in the controls (IgA: 100±47, 251±178, 80±24, 145±164 mg/L vs <67 mg/L, P <0.01; sIgA: 88±96, 326±237, 88±121, 104±109 mg/L vs 13±10 mg/L, P <0.01). IgA was positively correlated with sIgA(r = 0.4371, P <0.01). The levels of serum IgA and sIgA were markedly increased in patients with AH, CSH, CH and LC as compared with those in the controls (IgA: 3.1±1.1, 3.4±1.8, 3.3±1.7, 4.9±3.3 g/L vs 1.6±0.2 g/L, P <0.01; sIgA: 31.1±25.8, 80.3±25.4, 30.5±24.1, 50.0±20.5 µg/L vs 23.4±8.2 µg/L, P <0.01 or P <0.05). The fecal IgA and sIgA were not correlated with serum IgA and sIgA, and serum IgA was not correlated with serum sIgA (P >0.05). In patients with CH, CSH and LC, serum sIgA was significantly correlated with alkaline phosphatase (r = 0.523 0, P <0.01) and total bilirubin (r = 0.4 581, P <0.01). In patients with AH, serum sIgA level was correlated with alanine aminotransferase (r = 0.4 692, P <0.01), total bilirubin (r = 0.4 265, P <0.01).

    CONCLUSION: The detection of IgA and sIgA can be used in the clinical diagnosis of hepatic diseases.

    Key Words: IgA; sIgA; Hepatic disease

    Liu DY, Liu P. Changes of IgA and sIgA and its clinical significant in hepatic diseases. Shijie Huaren Xiaohua Zazhi 2005;13(18):2275-2277

    摘要

    目的:探讨肝脏病变时IgA和sIgA对临床诊断的意义.

    方法:肝病患者共168例,包括急性肝炎35例,慢性重症肝炎9例,慢性肝炎67例,肝硬化57例,用免疫速率比浊法检测IgA,用放射免疫分析法检测sIgA.

    结果:肝脏患者粪便IgA,sIgA均显著高于正常对照组 (IgA: 100±47, 251±178, 80±24, 145±164 mg/L vs <67 mg/L, P<0.01; sIgA: 88±96, 326±237, 88±121, 104±109 mg/L vs 13±10 mg/L, P<0.01),IgA和sIgA呈显著正相关 (r = 0.4371, P<0.01).血清中IgA和sIgA显著高于正常对照组( IgA: 3 ......

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