谷氨酰胺对大鼠肝脏缺血再灌注损伤时肝组织谷胱甘肽含量和细胞凋亡相关基因Bcl-2、Bax蛋白表达的影
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贾昌俊, 戴朝六, 张 旭, 徐 锋, 崔 凯 许
谷氨酰胺;肝脏缺血再灌注损伤;谷胱甘肽;Bcl-2;Bax,谷氨酰胺对大鼠肝脏缺血再灌注损伤时肝组织谷胱甘肽含量和细胞凋亡相关基因Bcl-2、Bax蛋白表达的影响,贾昌俊，戴朝六，张旭，徐锋，许永庆，
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贾昌俊，戴朝六，张旭，徐锋，许永庆，中国医科大学附属第二医院(盛京医院)肝胆外科辽宁省沈阳市 110004
崔凯，沈阳医学院附属中心医院普通外科辽宁省沈阳市 110024
贾昌俊，男，1977-07-24生，辽宁省沈阳市人，汉族，中国医科大学附属第二医院(盛京医院)肝胆外科医师，主要从事肝胆外科临床与基础研究.jiacj_sy@sina.com
辽宁省自然科学基金资助项目，No.20022063
通讯作者：戴朝六，110004，辽宁省沈阳市和平区三好街36号，中国医科大学附属第二医院(盛京医院)肝胆外科.daicl-sy@tom.com
电话：024-83955232 传真：024-83955092
收稿日期：2005-09-21 接受日期：2005-09-30
Effects of glutamine on glutathione content and expression of Bcl-2 and Bax protein during hepatic ischemia and reperfusion injury in rats
Chang-Jun Jia, Chao-Liu Dai, Xu Zhang, Feng Xu, Kai Cui, Yong-Qing Xu
Chang-Jun Jia, Chao-Liu Dai, Xu Zhang, Feng Xu, Yong-Qing Xu, Department of Hepatobiliary Surgery, the Second Affiliated Hospital (Shengjing Hospital) of China Medical University, Shenyang 110004, Liaoning Province, China
Kai Cui, Department of General Surgery, the Affiliated Central Hospital of Shenyang Medical College, Shenyang 110024, Liaoning Province, China
Supported by the Natural Science Foundation of Liaoning Province, No. 20022063
Correspondence to: Professor Chao-Liu Dai, Department of Hepatobiliary Surgery, the Second Affiliated Hospital (Shengjing Hospital) of China Medical University, 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. daicl-sy@tom.com
Received: 2005-09-21 Accepted:2005-09-30
Abstract
AIM: To investigate the effect of alanyl-glutamine dipeptiven(Ala-Gln) on the content of glutathione (GSH) and the expression of Bcl-2and Bax protein during hepatic ischemia and reperfusion injury (HIRI) inrats.
METHODS: A total of 48 Wistar rats were randomly divided intoglutamine group (group G) and control group (group C), which werepretreated with Gln and normal saline, respectively. The liver wassubjected to warm ischemia by Pringle method for 30 min, and thenreperfused. The serum samples were colleted 1 and 24 h after thereperfusion, and the level of serum ALT was measured ......
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