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EB潜伏膜蛋白表达与肠上皮化生胃黏膜幽门螺杆菌感染的相关性
http://www.100md.com 刘东屏,于继红,李茵茵,王炳元
EB潜伏膜蛋白;肠上皮化生;幽门螺杆菌,刘东屏,于继红,王炳元,,,李茵茵,,刘东屏,通讯作者:,Relationshipbetweenex
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     刘东屏,于继红,王炳元中国医科大学附属第一医院消化内科 辽宁省沈阳市 110001

    李茵茵,鞍山曙光医院肿瘤内科 辽宁省鞍山市 114000

    刘东屏, 女, 1963-11-14生, 辽宁省辽阳市人, 汉族, 1985年中国医科大学本科毕业, 1988年硕士研究生, 1998年博士研究生, 副教授, 硕士研究生导师, 主要从事消化道肿瘤的研究.

    通讯作者:刘东屏, 110001, 沈阳市和平区南京北街155号, 中国医科大学附属第一医院消化内科. dongpingl@yahoo.com.cn

    电话:024-23256666-6199 传真:23329171

    收稿日期:2005-05-23 接受日期:2005-06-08

    Relationship between expression of Epstein-Barr virus latent membraneprotein and H pylori infection in gastric mucosa withintestinal metaplasia

    Dong-Ping Liu, Ji-Hong Yu, Yin-Yin Li, Bing-Yuan Wang

    Dong-Ping Liu, Ji-Hong Yu, Bing-Yuan Wang, Department ofGastroenterology, the First Affiliated Hospital of China MedicalUniversity, Shenyang 110001, Liaoning Province, China

    Yin-Yin Li, Department of Oncology, Shuguang Hospital of Anshan,Anshan 114000, Liaoning Province, China

    Correspondence to: Dong-Ping Liu, Department of Gastroenterology,the First Affiliated Hospital of China Medical University, Shenyang110001, Liaoning Province, China. dongpingl@yahoo.com.cn

    Received:2005-05-23 Accepted:2005-06-08

    Abstract

    AIM: To observe the expression of Epstein-Barr virus latentmembrane protein(EBV-LMP) in different types of intestinalmetaplasia(IM), and to explore its relation with H pylori infection.

    

    METHODS:
One hundred and seventy-one patients with IM were diagnosedusing HE staining, and 30 normal cases were selected as controls.HID-AbpH2.5-PAS mucoprotein histochemical staining and SP histochemicalstaining were used to determine the subtypes of the IM and EBV-LMP,respectively. H pylori infection was examined by HE staining, Hpylori-DNA polymerase chain reaction, and enzyme linkedimmunosorbent assay.

    RESULTS:
There was no expression of EBV-LMP in the normal gastricmucosa, while the positive rate of EBV-LMP in the IM ones was 33.3% andthe EBV-LMP was mainly stained in the cell nuclei. The expression ofEBV-LMP in the IM mucosa was significantly higher than that in normalones(P = 0.000 187). The rate of H pylori infection was63.7% in the IM mucosa, which was correlated with IM (rs =0.275, P = 0.000 755). The rate of H pylori infection inthe IM mucosa with EBV-LMP expression was 63.2% (36/57), which wassignificantly higher than that in normal mucosa(P = 0.000 445). Hpylori infection was significantly related to the expression ofEBV-LMP in the IM mucosa (rs = 0.522, P = 0.000001)..

    CONCLUSION:
EBV-LMP is expressed in IM mucosa, and latent infectionof EBV exists in some of them. The expression of EBV-LMP issignificantly higher in each subtype of the IM mucosa than that in thenormal ones. H pylori expression is correlated with theexpression of EBV-LMP in IM mucosa.

    Key Words: Epstein-Barr virus latent membrane protein;Intestinal metaplasia; H pylori

    Liu DP, Yu JH, Li YY, Wang BY. Relationship between expression ofEpstein-Barr virus latent membrane protein and H pylori infectionin gastric mucosa with intestinal metaplasia ......

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