【摘要】目的探讨水蛭地龙注射液(疏血通)对原发性肾病综合征(PNS)的治疗作用及对血浆内皮素(ET)、D-二聚体(DD)的影响。方法将原发性肾病综合征患者68例随机分为治疗组及对照组各34例，对照组采用标准激素疗法及复方丹参注射液，治疗组在泼尼松治疗同时加用水蛭地龙注射液，治疗前及疗程结束后测定血浆ET及DD，比较各组在治疗前后其浓度变化。结果治疗组与对照组在治疗后尿蛋白、血浆ET及DD浓度均较治疗前有显著降低，差异具有显著性，而对照组、治疗组在治疗前后分别比较差异无显著性(P>0.05)。结论水蛭地龙注射液可减少原发性肾病综合征患者内皮素的释放和D-二聚体的生成，对肾病综合征具有治疗作用。

    【关键词】水蛭地龙注射液；肾病综合征；内皮素；D-二聚体

    Effect of shuizhi-dilong injection on concentrations of plasma endothelin andD-dimer in patients with primary nephrotic syndrome

    XUAN YonghuaLIU YunqiLiu Yuxiaet al

    Binzhou Vocational College,Binzhou 256624

    【Abstract】ObjectiveTo investigate the curative effects of Shuizhi-Dilong injection treating primary nephrotic syndrome(PNS).MethodsThe treated group(n=34)based on onventional therapy was treated with Shuizhi-Dilong injection infused intravenously,meanwhile the control group(n=34)treated with Danshen injection infused.Before and after therapy ......