【摘要】 目的 探讨橄榄—脑桥—小脑萎缩(OPCA)的临床表现和MRI特点，以获得对该疾病较全面的认识，有利于早期诊断，减少误诊率。方法 对12例OPCA的临床表现和MRI特征进行回顾性分析。结果 临床突出特点为缓慢进行性加重的共济失调、锥体外系、锥体束、大脑高级功能受损症状及眼球运动障碍等。MRI突出特点有：(1)脑干萎缩变细，以前后径变小更明显，其中脑桥形态改变更著；(2)两侧小脑对称性萎缩及两侧小脑半球体积变小，小脑横向增宽，脑回细而直呈“皱眉状”；(3)脑池及脑室增大，以桥前池及延髓前池增宽更明显。结论 鉴于MRI诊断本病的特异性和敏感性，强调对有上述临床表现的患者应及时行MRI检查。

    【关键词】 小脑疾病；萎缩；神经系统疾病；核磁共振成像；诊断

    Clinical manifestations for olivopontocerebellar atrophy and MR imaging

    WU Li-ming，KONG Xiang-quan.

    Integrated Chinese and Western Medicine Hospital of Wuhan,Wuhan 430022,China

    【Abstract】 Objective This paper inquires into the clinical manifestation of olivopontocerebellar atrophy (OPCA) and the character of MRI so that we obtain the comprehensive understanding of the disease，which is advantage for the early stage diagnosis and decrease of the rate of diagnostic error as well.Methods To recall and analyze twelve cases of OPCA clinical manifestations and MRI characters.Results The clinical manifestation for these cases are specifically showed as slow and deepen supply imbalance ......