桂麻_____桂麻合方；发热；前列腺素E2；环磷酸腺苷

桂麻合方对致热家兔血浆中前列腺素E2和环磷酸腺苷含量的影响

http://www.100md.com 《时珍国医国药》 2005年第10期

桂麻,,桂麻合方；发热；前列腺素E2；环磷酸腺苷,1实验材料,2实验方法,3结果,4讨论,参考文献：

     摘要：目的：揭示桂麻合方解热作用协同、拮抗关系的存在及产生的原因。方法：以耳缘静脉注射内毒素复制家兔发热模型，测量口服桂枝汤、麻黄汤及其合方后不同时间的体温采集耳缘静脉血，血液样品按环磷酸腺苷(cAMP)、前列腺素E2(PGE2)药盒要求处理。结果：家兔血中的PGE2和cAMP的变化与体温变化相平行，解热作用有协同或拮抗关系的存在。结论：桂麻合方在煎煮过程中的新整合对PGE2和cAMP含量产生影响，从而使其解热作用出现协同或拮抗关系。

    关键词：桂麻合方；发热；前列腺素E2；环磷酸腺苷

    Guima Composite Decoction's Effects on the cAMP and PGE2 in the Serum of Experimental Fever Rabbit

    LI Jinghua, GUO Yucheng, JIA Chunhua, LI Xiaojun, LIU Xiaogang, CUI Jian

    (Chengde Medical College, Chengde,Hebei 067000, China)

    Abstract:Objective:To reveal the existence of antagonistic or synergistic relationship between compositions of Mahuang and Guizhi decoction and the reason.Methods:Copy the family rabbit fever model by iv endotoxin (ET), take the temperature at different time points after administering Guizhi decoction, Mahuang decoction and their compositions, and then collect the vein blood, detect the cAMP and PGE2 in sample according to the specification.Results:The changes of the levels of PGE2 and cAMP are paralleled to the change of temperature. There exists an antagonistic of synergistic relationships in the defervescence effect.Conclusion:The new integrations produced in the process of decocting of Guima composite decoctions have influences on the levels of PGE2 and cAMP, which makes the defervescence effect produce the antagonistic or synergistic relationship. ......

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