【摘要】 目的 研究急性心肌梗死(AMI)早期生化标志物心型脂肪酸结合蛋白(H-FABP)、肌红蛋白(Mb)、C反应蛋白(CRP)在AMI早期诊断中的应用价值，并与肌钙蛋白Ⅰ(cTnI)比较，为AMI的早期诊断提供更理想的指标。方法 观察AMI患者36例，在不同的时间段测定H-FABP、Mb、CRP、cTnI并与40例健康人检测结果进行比较。结果 CRP在AMI发生4h后升高，在24h内均有较高水平，敏感性也较高。H-FABP与Mb在AMI发生后1h即开始升高，较CRP提前释放，持续至12h，且敏感性较高。H-FABP特异性高于Mb及CRP。cTnI在AMI发生1h后有阳性检出，但只有在6h后有较高的检出率，且持续时间较长。结论 H-FABP较CRP、Mb、cTnI对早期AMI(特别是6h内)更具诊断价值，cTnI为AMI的确定标志物，早期生化标志物H-FABP与cTnI一起可望成为AMI诊断的重要检测标志物。

    【关键词】 心肌梗死；心型脂肪酸结合蛋白；早期生化标志物

    Application of early biochemical markers of acute myocardial infarction in early detection of AMI

    XIONG Da-qian,LAN Qing-ping.

    Department of Laboratory,Affiliated Hospital of Chengdu Univevsity of TCM,Sichuan 610072,China

    【Abstract】 Objective To estimate the value of early biochemica markers heart-type fatty acid-binding prontein(H-FABP),myoglobin(Mb)and C-reactive protein(CRP)for early diagnosis of AMI and provide better criteria for it’s early diagnosis,bycomaring with the troponin I.Methods Data of H-FABP,Mb,CRP were detected in 36 confirmed AMI patiens at various time phases.It was compared with the results of 40 healthy subjects.Results The CRP activities increased at 4h after episode of AMI and reached to it’s higher levels during 24h.The H-FABP and Mb levels elevated at 1h after episode of AMI and to keeping 12h.The sensitive is high.They releas appeared earlier than CRP.The specificity of H-FABP was obviously superior to Mb and CRP.The cTnI can be detected and 1h after episode of AMI.The positive rate of cTnI is higher on 6h after episode of AMI and exist long time.Conclusion H-FABP is superior in diagnostic value of AMI early sign than CRP,Mb and cTnI.The cTnI is the golden standard for AMI the early biochemical marker H-FABP is an important maker for AMI with cTnI. ......