盐酸万乃洛韦微孔渗透泵控释片的制备及释药机理的研究
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隋 红, 李三鸣, 施 路, 戚秋鹏
(沈阳药科大学药学院，辽宁 沈阳，110016)
摘要：目的 制备盐酸万乃洛韦微孔渗透泵片，考察该制剂的释药影响因素及释药机理。方法 利用正交设计优化处方，根据不同时间累积释放度考察药物的释放情况。结果 盐酸万乃洛韦微孔渗透泵控释片体外释药速度较市售片缓慢、平稳。结论 本制剂释药速率随渗透压差减小而成比例减小,遵从以渗透压差为释药动力的释药模式，12 h内呈现良好的零级释放特征。
关键词：药剂学；微孔渗透泵；聚丙烯酸树脂RS PO；正交设计；盐酸万乃洛韦
中图分类号：R94 文献标识码：A
Preparation of valaciclovir hydrochloride micro-porous osmotic pump tablets and study on the mechanism of drug release
SUI Hong，LI San-ming，SHI Lu， QI Qiu-peng
(School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016，China)
Abstract：Objective To prepare oral micro-porous osmotic pump tablets and investigate the factors influencing the drug release and drug release mechanism..Methods The optimal formulation of micro-porous osmotic pump-controlled release tablets were screened by the orthogonal design. Results The valaciclovir hydrochloride micro-porous osmotic pump tablets were prepared, of which the release rate was slower than that of the commercial conventional tablets. Conclusions The release profile of this formulation fit to zero-order release mechanism during 12 h. The drug release rate decreased in proportion to the osmotic pressure difference, which proved its osmotic principle.
Key word：pharmaceutics； micro-porous osmotic pump； Eudragit RS PO； orthogonal design；valaciclovir hydrochloride
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