醒脑静注射乳剂处方及制备工艺的研究
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朱华桥，逄秀娟，王思玲
(沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要:目的 确定醒脑静注射乳剂的处方及制备工艺。方法 以注射用大豆磷脂、泊洛沙姆(poloxamer)为复合乳化剂，加入适量的稳定剂及助表面活性剂，用正交设计筛选处方和工艺，制备醒脑静注射乳剂。结果及结论 制得的醒脑静注射乳剂物理稳定性良好。
关键词；药剂学；处方筛选；制备工艺；正交试验；醒脑静注射乳剂
中图分类号： R943 文献标识码：A
Studies on the formulation and preparation technique of Xingnaojing parenteral emulsion
ZHU Hua-qiao，PANG Xiu-juan，WANG Si-ling
(School of Pharmacy，Shenyang Pharmaceutical University，Shenyang 110016,China)
Abstract: Objective To optimize the formulation and preparative procedure of Xingnaojing parenteral emulsion. Methods The emulsion were prepared using soybean phospholipids and poloxamer (F68) as the complex emulsifying agent .The stabilizing agent and cosurfactant were also added into the formulation. The formulation and preparation technique were selected by orthogonal experiment. Results and Conclusion The physical stability of Xingnaojing emulsion prepared was good, which provides a basis for the development of the product.
Key words: pharmaceutics; formulation screening; preparation technique; orthogonal experiment; Xingnaojing parenteral emulsion
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