罗红霉素包衣缓释微丸的体外释放研究
http://www.100md.com
| 第1页 |
| 第4页 |
参见附件(108KB，8页)。
佟 杰，王东凯
沈阳药科大学 药学院, 辽宁 沈阳 110016
摘要：目的 不同条件下罗红霉素包衣缓释微丸的体外释放。方法 用释放度测定法考察影响药物释放的各种因素。结果 致孔剂用量、包衣增重等是影响药物释放的关键因素。以甲基丙烯酸树脂Eudragit NE30D为包衣材料，温度为21～28 ℃， 包衣增重5%(w),致孔剂用量为乳糖占包衣增重10%，熟化24 h，所制微丸具有明显的缓释特性。结论 以甲基丙烯酸树脂Eudragit NE30D 作为包衣材料所得缓释微丸符合 24 h 缓释要求。
关键词：药剂学；包衣缓释微丸；挤出滚圆法；罗红霉素； 水分散体；甲基丙烯酸树脂
中图分类号: R94 文献标识码：A
The study of in vitro release of roxithromycin from sustained- released pellets
TONG Jie, WANG Dong-kai
(School of pharmacy , Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: objective To evaluate the in vitro release of roxithromycin from sustained-released pellets. Methods In vitro release was evaluated by the method for release determination described in the Ch.P. 2000 Ed. Result Amount of lactose in coating material, the coating thickness, etc, had significantly effects on the release rate. The profiles of sustained-release were obtained at the following condition: Eudragit NE30D as the coating material, coating temperature of 21~28 ℃, amount of lactose was 100 g·L-1 in coating material, increased weight on the pellets by coating material was 50g·L-1. Conclusion The prepared pellets met the release standard of 24 h sustained release formulation.
Key words: pharmaceutics；coated sustained-release pellets ; extrusion-spheronization method; roxithromycin; aqueous dispersion; Eudragit NE30D
您现在查看是摘要介绍页，详见PDF附件(108KB，8页)。