挤出滚圆法中各因素对微丸性质及药物释放的影响
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杨 蕾，关 颖，王永圣，崔福德
(沈阳药科大学 药学院，辽宁 沈阳 110016)
摘 要：目的 总结挤出滚圆法制备药用微丸过程中处方及工艺因素的影响。方法 收集和整理国内外相关文献，结合自身科研工作的经验，以微丸性质和药物释放为指标，考察挤出滚圆法的各影响因素。结果 处方组成及制备工艺对微丸的性质及释药均有不同程度的影响。 结论 通过控制挤出滚圆中各种参数，可获得粉体学性质良好，释放符合要求，载药量较高的微丸产品。
关键词： 药剂学；挤出滚圆；微丸性质；影响因素；药物释放；粉体学
中图分类号：R94 文献标识码：A
Various effects of extrusion-spheronization process on properties and drug release rate of pellets
YANG Lei, GUAN Ying, WANG Yong-sheng, CUI Fu-de
(College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To review the effects of formulations and extrusion- spheronization process factors on the quantity of pellets. Method According to plenty of articles concerned and experiments, this paper summarized various effects during the extrusion-spheronization process. Results It was showed that formulations and process factors during extrusion-spheronization influented the pellets’ properties prominently. Conclusion It is possible to obtain pellets with good micromeritics characteristics, appropriate drug release rate and high drug loading by adjusting formulations and factors during extrusion- spheronization process.
Key words: pharmaceutics; extrusion-spheronization; pellets property; effect factor; drug release; micromeritics
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