盐酸氯丙嗪在大鼠肠道的吸收动力学
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文章编号:(2005)03–0132–05,盐酸氯丙嗪在大鼠肠道的吸收动力学
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李国华，邹梅娟，程 刚，卢 懿，朱宗磊
(沈阳药科大学 药学院，辽宁 沈阳 110016)
摘要： 目的 探明盐酸氯丙嗪在肠道各区段的吸收动力学特征﹑吸收部位和吸收机制，为药物缓释制剂的设计提供重要的依据。方法 采用大鼠在体肠灌流吸收实验，研究了盐酸氯丙嗪的吸收部位和吸收动力学特征。结果 盐酸氯丙嗪在整个肠道均吸收良好，吸收速度常数依次为0.70、0.63、0.64、0.63 h-1。药物在肠道的吸收机制为被动吸收，药物的吸收窗为整个肠道。结论 盐酸氯丙嗪的吸收窗比较长，适合于制备日服1次的缓释给药系统。
关键词：药剂学；肠吸收；在体肠灌流；盐酸氯丙嗪
中图分类号：R94 文献标识码：A
Absorption kinetics of chlorpromazine hydrochloride in rats′intestines
LI Guo-hua, ZOU Mei-juan, CHENG Gang, LU Yi, ZHU Zong-lei
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)
Abstract: Objective To ascertain the absorption properties of chlorpromazine hydrochloride from various intestine segments in order to devise the sustained-release dosage forms of chlorpromazine hydrochloride.Methods The absorption kinetics and absorption site were investigated using in situ perfusion method in rats. Results It was showed that chlorpromazine hydrochloride was readily absorbed from the whole intestine. The absorption rate constants were 0.70, 0.63, 0.64, 0.63 h-1at duodenum, jejunum, ileum and colon respectively. Conclusion The absorption of chlorpromazine hydrochloride complies with the the passive transport mechanism chlorpromazine hydrochloride can be prepared and processed into sustained-release dosage forms for once a day.
Key word: pharmaceutics; intestine absorption; intestinal perfusion in vivo; chlorpromazine hydrochloride
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