阿昔洛韦输液剂的研究
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文章编号:(2003)04-0137-05,阿昔洛韦输液剂的研究
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毛世瑞， 刘进伟， 蔡翠芳， 毕殿洲
(沈阳药科大学药学院，辽宁 沈阳 110016)
摘要： 目的 研制阿昔洛韦输液剂。方法 采用HPLC法测定药物含量，考察影响因素，并采用恒温加速实验进行稳定性考察及安全性评价。结果 当阿昔洛韦与氯化钠配伍，溶液pH值为11.0时，该制剂稳定安全。结论 阿昔洛韦输液剂安全稳定，可供临床使用。
关键词：药剂学；输液剂； 处方设计；阿昔洛韦
中图分类号：R944 文献标识码：A
Studies on the preparation of acyclovir infusion
MAO Shi-rui ，LIU Jin-wei ，CAI Cui-fang ，BI Dian-zhou
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016,China)
Abstract: Objective To develop acyclovir infusion. Methods On the base of preformulation, the compatibility of acyclovir with several excipients was studied, and the content determination method of acyclovir and sodium chloride was established. Furthermore the stability of the formulation was investigated. Results When acyclovir and sodium chloride were made up together, the pH of the infusion was 11.0. The stability and quality of infusions were good. Conclusions The acyclovir infusion preparation is safe, stable and could be used in clinic.
Key words: pharmaceutics; infusion; formulation design; acyclovir
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