磷酸化黏着斑激酶在结肠癌中表达及意义
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刘启胜, 于红刚, 齐元玲, 曹 俊, 罗和生,
结肠癌;黏着斑激酶;磷酸化,刘启胜,于红刚,齐元玲,曹俊,罗和生,于皆平,通讯作者:,Expressionandsignificanceofphosphoryl
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刘启胜, 于红刚, 齐元玲, 曹俊, 罗和生, 于皆平, 武汉大学人民医院消化内科 湖北省武汉市 430060
国家自然科学基金资助项目, No.30470782
通讯作者: 于红刚, 430060, 湖北省武汉市, 武汉大学人民医院消化内科. wuzhixuan2003@126.com
电话: 027-88076874
收稿日期: 2005-09-28 接受日期: 2005-09-30
Expression and significance of phosphorylated focal adhesion kinase in colon carcinoma
Qi-Sheng Liu, Hong-Gang Yu, Yuan-Ling Qi, Jun Cao, He-Sheng Luo, Jie-Ping Yu
Qi-Sheng Liu, Hong-Gang Yu, Yuan-Ling Qi, Jun Cao, He-Sheng Luo, Jie-Ping Yu, Department of Gastroenterology, People’s Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Supported by National Natural Science Foundation of China, No. 30470782
Correspondence to: Hong-Gang Yu, Department of Gastroenterology, People’s Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. wuzhixuan2003@126.com
Received: 2005-09-28 Accepted: 2005-09-30
Abstract
AIM: To investigate the expression of phosphorylated focal adhesion kinase (phospho-FAK) and its signific-ance in human colon carcinoma.
METHODS: The phospho-FAK (including FAK) expre-ssion was detected by Western bloting in 20 cases of colon carcinoma and their corresponding para-cancer tissues.
RESULTS: The positive rate of FAK expression in the cancer tissues was significantly higher than that in the corresponding normal tissues (95% vs 60%, c2 = 5.16, P <0.05). The mean level of FAK expression in the cancer tissues was 0.482±0.150, while the mean level of expression in the normal tissue was 0.269±0.015 (t = 6.39, P <0.01). The positive rate of Tyr-397 FAK protein expression in the cancer tissues was 90%, while the positive rate in the corresponding normal tissues was only 20% (c2 = 17.1, P <0.01). The mean level of Tyr-397 FAK protein expression in the cancer tissue was notably higher than that in the corresponding para-cancer tissues (0.385±0.021 vs 0.110±0 ......
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