穴位经皮给药对痰热蕴肺型慢阻肺患者
穴位,,慢性阻塞性肺病；穴位经皮给药治疗；肺功能；肿瘤坏死因子α；白细胞介素2,1资料与方法,2结果,3讨论,参考文献:
摘要: 目的：探讨穴位经皮给药对痰热蕴肺型急性发作期慢阻肺(AECOPD)患者的疗效。方法：70例急性发作期的COPD患者随机分为治疗组(36例)和对照组(34例)，治疗组在常规治疗的基础上采用穴位经皮给药治疗，观察治疗2周后患者的咳、痰、喘等症状好转的情况。采用酶联免疫吸附(ELISA)方法测定70例慢阻肺急性发作期患者入院初及治疗后血清中的白细胞介素2(IL2)、肿瘤坏死因子α(TNFα)的水平，同时测定肺功能(FEV 1%pre、FEV1/FVC、MVV。结果：70例患者中有64例完成本实验。(1)治疗后2组中医证候积分均较治疗前明显改善(P<0.001)，治疗后2组中医证候积分比较差异无统计学意义(P>0.05)，治疗后2组综合疗效评定无统计学意义(P>0.05)。(2)2组治疗后FEV1%pre、FEV1/FVC均较治疗前明显改善(P<0.05)，但2组组间比较差异无统计学意义(P>0.05)。2组治疗后MVV均较治疗前明显改善，且治疗组改善优于对照组(P<0.05)。(3)治疗后2组TNFα浓度均明显下降，IL2浓度明显升高，且治疗组下降或升高的水平优于对照组(P<0.05)。结论：穴位经皮给药治疗后可明显改善患者的咳、痰、喘等临床症状，改善气道阻力及肺的通气功能。从对细胞因子的影响可推测穴位经皮给药可能具有调节患者细胞免疫和体液免疫的功能，增强患者抵抗力，有利于疾病的恢复。关键词: 慢性阻塞性肺病；穴位经皮给药治疗；肺功能；肿瘤坏死因子α；白细胞介素2
The study of the effect of point transcutaneoua application on pulmonary
function and cytokine of heatphlegm type COPD patientsWANG Ling, LI Fengsen, YANG Weijiang, et al
(Fourth Affiliated Hospital, Xinjiang Medical University, Urumqi 830000, China)Abstract: Objective：To discuss the curative effect of point transcutaneous application used in treating the acute exacerbations of heatphlegm type chronic obstructive pulmonary disease. Methods： The 70 patients with acute exacerbations of chronic obstructive pulmonary disease were randomly divided into treatment group(36cases) and control group(34cases), the treatment group was treated by point application on the basis of regular method. The symptoms such as cough, sputum and stridor etc of both groups who were treated by point application for two weeks were observed. The serum levels of IL2, TNFα both of the admission of hospital and after being treated by ELISA method were measured in these cases. Meanwhile the pulmonary function was also measured (FEV 1%pre、FEV1/FVC、MVV). Results：(1) The clinical symptoms of TCM on both treatment group and control group were improved obviously(P<0.01), and the effect of treatment group was better than that of the control group(P<0.05). There were not significant difference in statistics of the total efficiency (P>0.05). (2) After treatment, the levels of FEV 1%Pre, FEV1/FVC were better than before in two groups, no significant difference between both groups was found (P>0.05). After treatment the levels of MVV was improved in two groups and in the treatment group, it was better than that in the control group(P<0.05). (3)The level of TNF2 decreased and the level of IL2 increased in two groups after treatment, meanwhile in the treatment group those were better than those in the control group(P<0.05). Conclusion: It is obvious that the use of point application can improve the clinical symptoms of TCM and pulmonary ventilation function and decrease the airway resistance. We can infer that the treatment of point application may has not only the function to adjust cellular immunity and humoral immunity but also the power to reinforce patients’ resistance from the effect on cytokine. It benefits patients’ recovery. ......
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