糖尿病患者血浆肿瘤坏死因子α、内皮素、一氧化氮水平及临床意义
糖尿病,,2型糖尿病；肿瘤坏死因子α；内皮素；一氧化氮,1资料与方法,2结果,3讨论,参考文献:
摘要： 目的： 探讨血浆肿瘤坏死因子(TNFα)、内皮素(ET)和一氧化氮(NO)在2型糖尿病(DM)发生、发展中的作用。方法： 采用放免法和化学比色法测定89例DM患者(DM组)和51例健康体检者(对照组)空腹及餐后2 h外周血TNFα、ET、NO、胰岛素(Ins)和血糖(BG)水平，并进行对照分析。结果： DM组患者空腹血浆TNFα、ET、BG、Ins测定值均高于对照组(P<0.05～0.001)，而NO值显著低于对照组(P<0.05～0.001)，在合并微血管并发症者中这种变化尤为明显，DM组餐后2 h ET、BG、Ins测定值较空腹时增高(P<0.05～0.001)，TNFα、NO测定值则无明显变化。结论： TNFα、ET及NO水平升高在2型DM的病理过程中可能起一定作用。关键词： 2型糖尿病；肿瘤坏死因子α；内皮素；一氧化氮
A study of TNFa ET and NO in peripheral blood of patients with diabetes mellitus WANG Yongzhi, ZHU Guoping, WANG Yan, et al
(Department of Internal Medicine, Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China)
Abstract: Objective: To evaluate the role of TNFα, ET and NO in the pathogenesis of tyoe 2 diabetes mellitus (group DM). Methods: The levels of fasting and postprandial two hours TNFα, ET, NO blood Glucose (BG) and Insulin (Ins) in peripheral blood were measured by radioimmunorassay and chemocolorimetric analysis in 89 patients with DM and 51 healthy controls. Results: The levels of fasting serum TNFα, plasma ET, BG, Ins in patients with DM were significantly higher than those of healthy controls (P<0.05～0.001).But the levels of fasting NO was significantly lower than those of healthy ones(P<0.05～0.001)and the increased levels were more obviously in patient with microvascular complications than patients without those complications ones. But the values of FT, BG and Ins were significantly increased(P<0.05～0.001)and the levels of TNFα and NO were not statistic significant in those of postprandial two hours compared with fasting ones (P>0.05～0.001). Conclusions: The increased cytokines might play a role in the pathogenesis of type 2 DM. ......
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