【摘要】 目的 探讨还原型谷胱甘肽(GSH)对HIV/AIDS患者肝损害的治疗作用。方法 将HIV/AIDS患者肝功能异常60例随机分为两组，治疗组28例，静脉滴注GSH 1.2～1.8g，1次/d，连续用4周。对照组32例，静脉滴注维生素C 2.0g，肌苷1.0～2.0g，门冬氨酸钾镁20ml，茵栀黄30ml，1次/d，连续用4周。结果 治疗组和对照组丙氨酸转氨酶(ALT)，天冬氨酸转氨酶(AST)的显效率分别为78.6%(22/28)和12.5%(4/32)，总有效率分别为89.3%(25/28)和40.6%(13/32)；γ-谷氨酸转氨酶(γ-GT)，总胆红素(TB)，直接胆红素(DB)的显效率分别为17.9%(5/28)和6.3%(2/32)，总有效率分别为78.6%(22/28)和53.1%(17/32)。治疗组疗效明显优于对照组，两组比较，差异有非常显著性(P<0.01)，两组血清蛋白(ALB)的显效率分别为7.2%(2/28)和6.3%(2/32)，总有效率分别为42.9%(12/28)和37.5%(12/32)。两组比较，差异无显著性(P>0.05)。结论 GSH治疗HIV/AIDS患者肝功能损害疗效明显，可作为HIV/AIDS患者肝功能损害的首选用药。

    关键词 还原型谷胱甘肽 HIV/AIDS 肝损害 疗效

    The effect of glutathione on patients of HIV/AIDS with hepatic damage

    Qi Yanwei,Li Zhuoming,Li Junyi,et al.

    The Third People's Hospital of Kunming Yunnan 650041.

    【Abstract】 Objective To study the therapeutic effect of GSH on the patients of HIV/AIDS with hepatic damage,which were randomly divided into 2 groups,the patients receiving GSH for 1.2～1.8g per day through intravenous drip for 4weeks and the vitaminc for 2.0～3.0g,kalli magnesii aspartatis for 20ml and yinzhihuang for 30ml every day through intravenous drip for 4 weeks as control group(n=32).Results The efficacy rates judged by alanine aminotransferase(ALP),aspartate aminotransferase(AST) were 78.6%(22/28) in the treatment group and 9.4%(3/32) in the control group with the total efficacy rates of 89.3%(25/28) and 31.3%(10/32),respectively,The efficacy rates judged by gamma-glutamyl transpeptidase(r-GT) total bilirubin(TB) and direct bilirubin(DB) were 17.9%(5/28) in the treatment group and 6.3%(2/32) in the control group with the total efficacy rate of 78.6%(22/28) and 37.5%(12/32),respectively.The curative effect of GSH in the treatment group was better significantly than that of the drugs in the control group(P<0.01).The efficacy rates judged by albumin(ALB) were 7.2%(2/28)in the treatment group and 6.3%(2/32) in the control group with the total efficacy rates of 42.9%(12/28) and 37.5%(12/32),respectively.There was no statistical difference between the 2 group(P>0.05).Conclusion GSH is a rapid and effective safe drug in treating the damaged liver in the patients of HIV/AIDS.It can be adopted as a first-selective drug. ......