摘要: 目的：探讨凯西莱(硫普罗宁)治疗肝硬化、改善肝脏功能的疗效。方法：对我科88例确诊肝硬化失代偿期的患者分为2组，对照组应用常规护肝药物治疗，治疗组再加用凯西莱针剂0.2 g静点，治疗2～3周，门诊随访患者肝功能的变化情况。结果：治疗组：ALT(谷丙转氨酶)、 AST(血清谷草转移酶) 、TB(总胆红素)及PT(凝血时间)下降幅度与对照组比较，差异有统计学意义(P<0.05)。患者乏力、腹胀等症状改善，与对照组比较差异有统计学意义(P<0.05)。结论：凯西莱能改善肝硬化患者肝功能，并有一定的促进肝细胞再生作用。

    关键词：肝硬化；凯西莱(硫普罗宁)；肝功能指标

    The Clinical Effect of Tiopronin with Hepatic CirrhosisGUAN Li, YAO Ping

    Department of Gastroenterology, First Affiliated Hospital, Xinjiang Medical Uniuersity,

    Urumqi 830054， China)Abstract: Objective: To exploit therapeutic effects of tiopronin and improvement of hepatic function for patients with cirrhosis. Methad: Two groups were devided casually. Conventional drugs for protecting hepatic function in contrast group while Tiopronin 0.2g iv drip daily for 2~3 weeks was added in therapeutic group. Then the changes of patients' hepatic function in the two groups were obseryed . Result: In therapeutic group: ALT AST TB and PT decreased obviously than in contrast group. (P<0.05) and improved distinctively tiredness bloating. Conclusion: Tiopronin can evidently improve hepatic function of patients with cirrhosis and promote hepatocellular regeneration partially. ......