胃肿瘤_____胃肿瘤·血管生成拟态·血管生成抑制剂

TNP470对胃癌细胞株SGC7901体外血管生成拟态的抑制作用

http://www.100md.com 《中国普通现代外科进展》 2005年第4期

胃肿瘤,,胃肿瘤·血管生成拟态·血管生成抑制剂,1材料与方法,2结果,3讨论,参考文献

     【摘要】目的：研究TNP470对胃癌细胞株SGC7901体外血管生成拟态的影响。方法：将培养的SGC7901细胞分为TNP470组及对照组，应用克隆形成试验检测细胞增殖活性的变化。Transwell小室检测癌细胞体外侵袭力的变化，体外管状形成试验检测管道形成能力的变化。结果：TNP470对SGC7901细胞增殖没有明显抑制作用，可以显著降低SGC7901细胞的体外侵袭能力，抑制体外管道形成。结论：TNP470能够抑制SGC7901细胞的体外血管生成拟态形成。

    【关键词】胃肿瘤·血管生成拟态·血管生成抑制剂

    Inhibitive effect of TNP470 on vasculogenic mimicry in gastric cancer cell line SGC7901 in vitro

    WU Qing,SUN Qilong,DING Yinlu,LI Zhaoting

    1Department of General Surgery,Qilu Hospital of Shandong University(Jinan 250012,China)

    2Department of General Surgery,the Second Affiliated Hospital of Shandong Univer

    sity(Jinan 250033,China)

    【ABSTRACT】Objective:To investigate the effect of TNP470 on the vasculogenic mimicry in gastric cancer cell line SGC7901 in vitro.Methods:Cultured SGC7901 cells were devided into TNP470 group and control group.The effect of proliferation,invasion and tube formation on SGC7901 cells were detected by colone formation assay,invasion assay and tube formation assay respectively in vitro.Results:Number of colone formation of TNP470 group was not significantly lower than the control group(P0.05),the number of cells which crossed to the lower surface of the matrigelcoated filters in TNP470 group was significantly lower than the control group(P0.01).Tube formation could be inhibited by TNP470.Conclusion:TNP470 can inhibit the vasculogenic mimicry formation of gastric cancer cell line SGC7901 in vitro. ......

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