鼻炎_____鼻炎清颗粒；变应性鼻炎；细胞因子；嗜酸性细胞

鼻炎清颗粒对大鼠变应性鼻炎IL4、IFNr水平的调节作用

http://www.100md.com 《新疆医科大学学报》 2005年第8期

鼻炎,,鼻炎清颗粒；变应性鼻炎；细胞因子；嗜酸性细胞,1材料与方法,2结果,3讨论,参考文献:

     摘要: 目的: 观察鼻炎清颗粒治疗大鼠变应性鼻炎(AR)后鼻粘膜组织形态学变化和细胞因子水平,探讨该药治疗AR的部分免疫学机制。方法: 用卵清白蛋白、氢氧化铝、百白破疫苗联合致敏大鼠制成变应性鼻炎动物模型,将鼻炎清颗粒灌胃给药2周后,观察鼻粘膜组织学变化,用ELISA法检测血清中细胞因子IL4、IFNr水平。结果: 鼻炎清颗粒治疗组中大剂量组和中剂量组血清1L4水平明显低于模型组,差异有统计学意义(P<0.01～0.05)；IFNr水平明显高于模型组,差异有统计学意义(P<0.01)；光镜观察发现,模型组鼻粘膜上皮细胞脱落、水肿、血管扩张、腺体增生,固有层内可见大量嗜酸性粒细胞、肥大细胞浸润,用药组中大剂量组和中剂量组及阴性对照组则无上述改变。结论:鼻炎清颗粒通过调节Th1和Th2细胞因子的表达,纠正失衡的Th1/Th2的细胞因子网络并抑制炎症细胞在鼻粘膜的汇集,防止其脱颗粒,对变应性鼻炎产生治疗作用。

    关键词：鼻炎清颗粒；变应性鼻炎；细胞因子；嗜酸性细胞

    Regulate effection of interleukin4， interferonγ in serum of allergic rhinitis in rat by using rhinitis clean granula

    Saltanat， WU Xinhua， XU Yan， et al

    (Department of Clinical Laboratory, Second Affiliated Hospital, Xinjiang Medical University,Urumqi 830054, China)

    Abstract: Objective: To study the influence of Biyanqing(Rhinitis clean granula, RCG) on serum concentration of cytokine in allergic rhinitis model and the morphologic changes. Methods: Establish allergic rhinitis model of rat by injecting vaccine (OVA+Alumina+polyvalent vaccine). After that rats were with filled stomach RCG. Two weeks later the levels of serum cytokines IL4, IFNγ were determined by ELISA , and observe the changes of nose mucosa by light microscope. Results: After the treatment by using RCG, the levels of Serum IL4 in both highdosage and middledosage therapy groups were lower than that in mode group that arkedly (P<0.01 and P<0.05). The levels of serum IFNγ in both highdosage and middledosage therapy groups were higher than that in model group markedly (P<0.01)； Under light microscope ......

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