【摘要】 目的 比较 99 Tc-MDP与中药处方骨密Ⅲ号联合治疗与第三代磷酸盐药物氨基二磷酸盐对骨质疏松动物模型的疗效的价值。 方法 应用药物盐酸地塞米松诱导制作兔骨质疏松动物模型，分别应用 99 Tc-MDP联合骨密Ⅲ号治疗和氨基二磷酸盐治疗兔骨质疏松动物模型，治疗16周后进行X线摄片、CT、核素骨显像、骨细胞学、骨形态计量、骨密度及骨生物力学测定。 结果 99 Tc-MDP联合骨密Ⅲ号治疗组和氨基二磷酸盐治疗组与骨质疏松对照组比较:骨形体计量分别上升166.88%、65.66%;腰椎骨密度分别上升28.28%、13.13%;股骨头骨密度上升30.03%、16.50%;核素骨显像差值上升30.72%、25.64%;生物力学上升26.94%、15.57%。骨细胞学也有明显的改变。 结论 99 Tc-MDP联合骨密Ⅲ号治疗既有双磷酸盐的作用又具有活血、补肾、壮骨等功能。可能对骨组织的生长和代谢起到较明显支持、促进作用。

    【关键词】 99 Tc-MDP;骨密Ⅲ号;氨基二磷酸盐;骨质疏松动物模型;治疗

    The comparative study between99 Tc-MDP combined with GUMIⅢand amino-diphosphate in the treatment of animal osteoporosis model

    GAO Ke-jia，ZHAO Guo-ding，LI Zong-ju，et al.

    Shanghai Huangpu Distric Central Hospital，Nuclear Medicine Department，Shanghai200002，China

    【Abstract】 Objective To compare the clinical value between 99 Tc-MDP combined with GUMIⅢand amino-diphosphate in the treatment of animal osteoporosis model.Methods After the animal osteoporosis model induced by dexamethasone hydrochloride was set up，the rabbits were separate into3groups，in2groups of them were treated re-spectively by isotope drug 99 Tc-MDP together with GUMIⅢand aminodiphosphate ......