【摘要】 目的 评估丙戊酸快速静滴控制癫痫持续状态(SE)的有效性和安全性。方法 收集和分析63例接受过静脉滴注丙戊酸治疗的癫痫持续状态患者资料，包括：一般资料、SE病因、合并症、治疗时间、先前抗癫痫药物(AED)的使用、丙戊酸制剂(VPA)静脉滴注的浓度和速度，安全性和有效性。结果 VPA对SE总有效率为63.3%，治疗开始时间和合并症是疗效强有力的预测因子。患者能很好地耐受快速静脉使用VPA。结论 快速静脉使用VPA治疗癫痫持续状态是有效和安全的。

    【关键词】 丙戊酸；癫痫持续状态；快速静脉使用

    Clinical research of rapid IV administration of valproic acid for status epilepticus

    CHU Xu-hua,XU Zhu-qing,WANG Guo-xiang.

    The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China

    【Abstract】 Objective To valuate efficacy and safty of rapid IV administration of valproic acid for status epilepticus.Methods The authors reviewed 63 patients (30 men) with SE treated with IV VPA (average dose,31.5mg/kg).Analysis of demographic,clinical,and treatment information was made.Results The overall efficacy of VPA in SE was 63.3%,with time to treatment and comorbidity being strong predictors.Rapid administration of VPA was well tolerated.Conclusion Rapid IV administration of valproic acid for status epilepticus is efficacious and safty. ......