摘要: 目的： 探讨轻、重度先兆子痫患者肝肾功能指标的变化及其临床意义。方法：对152例先兆子痫患者的肝功能指标白蛋白(Alb)、球蛋白(GT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)和163例先兆子痫患者的肾功能指标尿素氮(BUN)、尿酸(UA)、肌酐(Cr)进行了回顾性分析，并对先兆子痫患者肝酶水平与母儿预后的关系及血清UA水平与围产儿预后的关系进行了研究。结果：重度先兆子痫患者血清中Alb、GT明显低于轻度先兆子痫患者(P<0.01)，ALT、AST明显高于轻度先兆子痫患者(P<0.01)；先兆子痫患者中肝酶异常与肝酶正常者新生儿窒息、围产儿死亡、产后出血发生率及新生儿体重差异均无统计学意义(P>0.05)；重度先兆子痫患者UA、Cr水平明显高于轻度先兆子痫患者(P<0.01)；围产儿死亡发生率随UA水平升高而升高(P<0.05)。结论：重度先兆子痫患者肝肾功能有一定损害 ，肝酶异常对母儿预后的影响不明显。先兆子痫孕妇的血清UA与围产儿预后密切相关，可作为判断围产儿预后及终止妊娠的一项参考指标。

    关键词：轻度先兆子痫；重度先兆子痫；肝功能；肾功能；围产儿结局

    Changes of biochemical indexes of liver and kidney function in mild and severe preeclampsia and the clinical value of the changes

    Abida， CAI Xia

    (Department of Obstetrics and Gynecology，First Affiliated Hospital，Xinjiang Medical University，Urumqi 830054，China)

    Abstract: Objective：To compare the biochemical indexes of the liver and kidney function in patient with severe and mild preeclampsia, and analyze the clinical value of the changes to evaluate the severity and perinatal prognosis. Methods: Retrospective analysis were performed on patients with preeclampsia who had been hospitalized in our department in last five years. Results：In severe preeclampsia group the proteins Alb, GT were lower than those in the mild preeclampsia group whereas ALT, AST were higher. Liver enzymes showed a significant increase in severe preeclampsia. Liver enzymes abnormality occurs in about 23.03% of preeclampsia patients. The abnormality of liver enzymes did not lead to an increase in the incident of postpartum hemorrhage and negative perinatal outcome. The blood level of UA, Cr was higher amongst severe preeclampsia patients ......