摘要：目的 探讨贺斯(HES)在体外循环(CPB)手术中对血流动力学及凝血功能的影响，明确HES在心血管手术中的应用价值。方法 选择40例行冠状动脉旁路移植术(CABG)的患者,随机分为HES组和佳乐施(GEL)组。HES组：在CPB前、CPB中用HES液静脉滴注和预充；GEL组：作对照，在CPB前、CPB中用GEL液静脉滴注和预充。观察给药前，给药后10min，停机后1h、4h和24h的血流动力学、氧供、氧耗和凝血功能指标。结果 两组患者各血流动力学、氧供和氧耗指标、凝血功能指标比较差别均无显著性意义(P>0.05)。结论 HES适用于CPB手术，对血流动力学和凝血功能均无明显影响。

    关键词：贺斯；佳乐施；体外循环；冠状动脉旁路移植术

    The Effect of Hydroxyethyl Starch on Hemodynamics and Coagulation In the Operation with Cardiopulmonary Bypass

    WANG Gu-yan,ZHAN Shu-gui, YU Li, Lin Xue,CHEN Lei

    ( Department of Anesthesiology, Cardiovascular Institute and Fu Wai Hospital,CAMS and PUMC, Beijing 100037)

    Abstract: OBJECTIVE To observe the effect of 6% hydroxyethyl starch (HES) for priming and volume replacement on hemodynamics and coagulation in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), and to arsert the utility of HES in cardiovascular surgery. METHODS Forty patients undergoing coronary artery bypass graft (CABG) were divided randomly into two groups: Group HES, using HES for priming and volume replacement before and during CPB; Group GEL, using GEL for priming and volume replacement before and during CPB. The hemodynamic data, oxygen delivery (DO2), oxygen consumption (VO2), and coagulation function were measured in the two groups before priming the fluid, 10 minutes after priming the fluid, 1hour, 4hours, and 24 hours after CPB, respectively. RESULTS There is no significant difference between these two groups in terms of hemodynamic data, DO2, VO2, and coagulation function (P>0.05).CONCLUSION HES, without significant effect on hemodynamics and coagulation function, can be used in cardiac surgery with CPB. ......