【摘要】 目的 探讨不同剂量比索洛尔(康可)对心力衰竭(简称心衰)的治疗效果，促进β受体阻滞剂在心衰治疗中的应用。方法 106例心衰患者随机分为康可2.5mg/d(A组)和康可5～7.5mg/d治疗组(B组)，观察主要事件和指标的变化。结果 康可5～7.5mg/d治疗组较康可2.5mg/d组，心衰恶化及再住院显著减少，NYHA心功能和EF显著改善，对血压和心率控制更理想。结论 大剂量比索洛尔能更好地保护心脏，应积极使用β受体阻滞剂治疗心衰。

    【关键词】 比索洛尔；β受体阻滞剂；剂量；心力衰竭

    Therapeutic effect on treating heart failure with different doses of bisoprolol

    TANG Biao,LIU Ju-fang.

    Department of Medicine,People’s Hospital of Yuechi County,Sichuan 638300,China

    【Abstract】 Objective To test the effect on treating heart failure (HF) with β receptor blocker,improve the application of β receptor blocker on treating HF.Methods 106 patients with HF (NYHA degrees 2～4) were divided into Group A and Group B,Group A contains 51 patients with bisoprolol 2.5mg/d,and Group B contains 55 patients with bisoprolol 5～ 7.5mg/d orally respectively.Therapeautic effect were observed after 3～15 months in the followed.Results HF deterioration and rehospitalization in Group B is significantly lower (P<0.05).LVEF and NYHA degrees in Group B is significantly increased (both P<0.05).Conclusion The higher dose of bisoprolol is possibly more benefit to HF. ......