可溶性白细胞介素_

丙型肝炎病毒感染血清中3种细胞因子水平的研究

http://www.100md.com 《新疆医科大学学报》 2005年第4期

可溶性白细胞介素,,可溶性白细胞介素2受体；肿瘤坏死因子α；白细胞介素6；丙型肝炎病毒,1材料与方法,2结果,3讨论,参考文献:

     摘要：目的：探讨血清中可溶性白细胞介素2受体(sIL2R)水平、肿瘤坏死因子α(TNFα)和白细胞介素6(IL6) 水平及其在检查丙型肝炎病毒感染中的意义。方法：应用ELISA方法检测42例正常人以及87例丙型肝炎患者血清中sIL2R、TNFα和IL6水平。将病人分为3组:A组：抗HCVAb(-),HCV RNA(+)。B组：抗HCVAb(+),HCV RNA(-)。C组：抗HCVAb(+),HCV RNA(+)。结果：3组病人血清中sIL2R、TNFα和IL6水平较正常人均明显增高(P<0.01)，3组间sIL2R、TNFα和IL6水平比较，除A、C组外，A、B组之间、B、C组之间差异均有统计学意义(P<0.01)。结论：sIL2R、TNFα和IL6水平的检测可作为丙型肝炎诊断的指标之一。

    关键词：可溶性白细胞介素2受体；肿瘤坏死因子α；白细胞介素6；丙型肝炎病毒

    The levels of three kinds of cytokines in the serum of human infected by hepatitis C virus

    WANG Song, ZHU Ming, WANG Xiaolan, et al

    (Department of Immunology, Xinjiang Medical University, Urumqi 830054, China)

    Abstract: Objective: To evaluate the levels of soluble interleukin2 receptors (sIL2R), tumor necrosis factor alpha(TNFα) and interleukin6 in serum and its value of examination for hepatitis C. Methods: The levels were detected in serum of 87 cases with hepatitis C and 42 normal persons by using ELISA method. In addition, the authors divided all of the patients into three groups that included the group A 〔HCVAb(-), HCV RNA(+)〕, the group B 〔HCVAb(+),HCV RNA(-)〕 and the group C 〔HCVAb(+),HCV RNA(+)〕. Results: The results showed that the levels of sIL2R, TNFα and IL6 were significantly increased in serum of 87 patients and each group (P<0.01) as compared with the control group. The remarkable difference still happened in comparison with patient's groups each other except between A and C. Conclusions: The authors, therefore, think that to survey the levels of sIL2R, TNFα and IL6 may be regarded as an indicator to diagnose hepatitis C. ......

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